INSTITUT FÜR MOLEKULARE UND KLINISCHE IMMUNOLOGIE

Publikationen 2022

Baldauf CK, Müller P, Haage TR, Adam-Frey S, Lokau J, Garbers C, Fischer T.
Anti-IL-6 cytokine treatment has no impact on elevated hematocrit or splenomegaly in a polycythemia vera mouse model.
Blood Adv. 2022 Jan 25;6(2):399-404. doi: 10.1182/bloodadvances.2021004379.

Bhuria V, Baldauf CK, Schraven B, Fischer T.
Thromboinflammation in Myeloproliferative Neoplasms (MPN)-A Puzzle Still to Be Solved.
Int J Mol Sci. 2022 Mar 16;23(6):3206. doi: 10.3390/ijms23063206.

Böttcher M, Böttcher-Loschinski R, Kahlfuss S, Aigner M, Gießl A, Mackensen A, Schlötzer-Schrehardt U, Tüting T, Bruns H, Mougiakakos D.
CLL-Derived Extracellular Vesicles Impair T-Cell Activation and Foster T-Cell Exhaustion via Multiple Immunological Checkpoints.
Cells. 2022 Jul 12;11(14):2176. doi: 10.3390/cells11142176.

Böttcher-Loschinski R, Rial Saborido J, Böttcher M, Kahlfuss S, Mougiakakos D.
Lipotoxicity as a Barrier for T Cell-Based Therapies.
Biomolecules. 2022; 12(9):1182. https://doi.org/10.3390/biom12091182

Cammann C, Israel N, Frentzel S, Jeron A, Topfstedt E, Schüler T, Simeoni L, Zenker M, Fehling HJ, Schraven B, Bruder D, Seifert U.
T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation.
Front Immunol. 2022 Aug 2;13:958616. doi: 10.3389/fimmu.2022.958616. PMID: 35983034; PMCID: PMC9379337.

Figueiredo CA, Steffen J, Morton L, Arumugam S, Liesenfeld O, Deli MA, Kröger A, Schüler T, Dunay IR.
Immune response and pathogen invasion at the choroid plexus in the onset of cerebral toxoplasmosis.
J Neuroinflammation. 2022 Jan 13;19(1):17. doi: 10.1186/s12974-021-02370-1.

Fischer V, Ragipoglu D, Diedrich J, Steppe L, Dudeck A, Schütze K, Kalbitz M, Gebhard F, Haffner-Luntzer M, Ignatius A.
Mast Cells Trigger Disturbed Bone Healing in Osteoporotic Mice.
J Bone Miner Res. 2022 Jan;37(1):137-151.

Franz T, Negele J, Bruno P, Böttcher M, Mitchell-Flack M, Reemts L, Krone A, Mougiakakos D, Müller AJ, Zautner AE, Kahlfuss S.
Pleiotropic effects of antibiotics on T cell metabolism and T cell-mediated immunity.
Front Microbiol. 2022 Oct 18;13:975436.

Franz T#, Negele J#, Kahlfuss S.
Cytotoxic innate lymphoid cells sense tumor-derived IL-15: A novel mechanism of cancer immunosurveillance.
Signal Transduct Target Ther. 2022 Sep 17;7(1):326. #Co-First authors

French T, Steffen J, Glas A, Osbelt L, Strowig T, Schott BH, Schüler T, Dunay IR.
Persisting Microbiota and Neuronal Imbalance Following T. gondii Infection Reliant on the Infection Route.
Front Immunol. 2022 Jul 11;13:920658. doi: 10.3389/fimmu.2022.920658.

Gelmez E, Lehr K, Kershaw O, Frentzel S, Vilchez-Vargas R, Bank U, Link A, Schüler T, Jeron A, Bruder D.
Characterization of Maladaptive Processes in Acute, Chronic and Remission Phases of Experimental Colitis in C57BL/6 Mice.
Biomedicines. 2022 Aug 5;10(8):1903. doi: 10.3390/biomedicines10081903.

Hammerschmidt SI, Thurm C, Bošnjak B, Bernhardt G, Reinhold A, Willenzon S, Ritter C, Reinhold D, Schraven B, Förster R.
Robust induction of neutralizing antibodies against the SARS-CoV-2 Delta variant after homologous Spikevax or heterologous Vaxzevria-Spikevax vaccination.
Eur J Immunol. 2022 Feb;52(2):356-359. doi: 10.1002/eji.202149645. Epub 2022 Jan 7.

Kästle M, Merten C, Hartig R, Plaza-Sirvent C, Schmitz I, Bommhardt U, Schraven B, Simeoni L.
Y192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection.
Int J Mol Sci. 2022 Jun 30;23(13):7271.

Knop L, Spanier J, Larsen PK, Witte A, Bank U, Dunay IR, Kalinke U, Schüler T.
IFNAR signaling in fibroblastic reticular cells can modulate CD8+ memory fate decision.
Eur J Immunol. 2022 Apr 1. doi: 10.1002/eji.202149760. Online ahead of print.

Krone A, Fu Y, Schreiber S, Kotrba J, Borde L, Nötzold A, Thurm C, Negele J, Franz T, Stegemann-Koniszewski S, Schreiber J, Garbers C, Shukla A, Geffers R, Schraven B, Reinhold D, Dudeck A, Reinhold A, Müller AJ, Kahlfuss S.
Ionic mitigation of CD4+ T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc.
Sci Rep. 2022 Feb 4;12(1):1943. doi: 10.1038/s41598-022-04827-6.

Lang JC, Seiß EA, Moldovan A, Müsken M, Sauerwein T, Fraunholz M, Müller AJ, Goldmann O, Medina E.
A Photoconvertible Reporter System for Bacterial Metabolic Activity Reveals That Staphylococcus aureus Enters a Dormant-Like State to Persist within Macrophages.
mBio. 2022 Sep 14:e0231622.

Lenk L, Winterberg D, Vogiatzi F, Laqua A, Spory L, Mayar A, Dietterle A, Münch G, Vokuhl C, Richter J, Polson AG, Schüler T, Kahlert UD, Peipp M, Valerius T, Schrappe M, Cario G, Jumaa H, Hobeika E, Brüggemann M, Alsadeq A, Schewe DM.
Preclinical Evidence for the Efficacy of CD79b Immunotherapy in B-cell Precursor Acute Lymphoblastic Leukemia.
Hemasphere. 2022 Jul 15;6(8):e754.

Meltendorf S, Vogel K, Thurm C, Prätsch F, Reinhold A, Färber J, Heuft HG, Kaasch AJ, Hachenberg T, Weinzierl S, Schraven B, Reinhold D, Brunner-Weinzierl MC, Lingel H.
IL-13 determines specific IgE responses and SARS-CoV-2 immunity after mild COVID-19 and novel mRNA vaccination.
Eur J Immunol. 2022 Oct 22. doi: 10.1002/eji.202249951.

Möckel M, Baldok N, Walles T, Hartig R, Müller AJ, Reichl U, Genzel Y, Walles H, Wiese-Rischke C.
Human 3D Airway Tissue Models for Real-Time Microscopy: Visualizing Respiratory Virus Spreading.
Cells 2022, 11, 3634. DOI: 10.3390/cells11223634

Müller P, Baldauf CK, Haage TR, Charakopoulos E, Böttcher M, Bhuria V, Mougiakakos D, Schraven B, Fischer T.
Genetic Knock-out of TNFR1 and TNFR2 in a JAK2-V617F Polycythemia Vera Mouse Model.
Hemasphere. 2022 Apr 15;6(5):e717.

Negele J#, Franz T#, Kahlfuss S*.
T-Zell-Metabolismus: Potenzial für Diagnostik und Therapie
Trillium Diagnostik, 2/2022. #First-authors *Corresponding author

Papaxenopoulou LA, Zhao G, Khailaie S, Katsoulis-Dimitriou K, Schmitz I, Medina E, Hatzikirou H, Meyer-Hermann M.
In silico predicted therapy against chronic Staphylococcus aureus infection leads to bacterial clearance in vivo.
iScience. 2022 Nov 8;25(12):105522.

Prat-Luri B, Neal C, Passelli K, Ganga E, Amore J, Firmino-Cruz L, Petrova TV, Müller AJ, Tacchini-Cottier F.
The C5a-C5aR1 complement axis is essential for neutrophil recruitment to draining lymph nodes via high endothelial venules in cutaneous leishmaniasis.
Cell Rep. 2022 May 3;39(5):110777.

Ragipoglu D, Bülow J, Hauff K, Voss M, Haffner-Luntzer M, Dudeck A, Ignatius A, Fischer V.
Mast Cells Drive Systemic Inflammation and Compromised Bone Repair After Trauma.
Front Immunol. 2022 Apr 26;13:883707. doi: 10.3389/fimmu.2022.883707.

Roder M, Kahlfuss S*.
Implementation of Immunometabolism into Curricula, Scientific Societies, and Immunological Routine Diagnostics.
J Immunol Sci. 2022 Dec 19. *Corr. author

Rücker FG, Du L, Luck TJ, Benner A, Krzykalla J, Gathmann I, Voso MT, Amadori S, Prior TW, Brandwein JM, Appelbaum FR, Medeiros BC, Tallman MS, Savoie L, Sierra J, Pallaud C, Sanz MA, Jansen JH, Niederwieser D, Fischer T, Ehninger G, Heuser M, Ganser A, Bullinger L, Larson RA, Bloomfield CD, Stone RM, Döhner H, Thiede C, Döhner K.
Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study results.
Leukemia. 2022 Jan;36(1):90-99.

Schultz A, Schnurra M, El-Bizri A, Woessner NM, Hartmann S, Hartig R, Minguet S, Schraven B, Simeoni L.
A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling.
Cells. 2022 Sep 1;11(17):2723.

Spindler M, Bergmeier W, Stradal TEB, Zhang J, Siminovitch K, Nicolai L, Reinhold A, Bender M.
Novel insights into mouse models of ectopic proplatelet release.
Blood Adv. 2022 Oct 17:bloodadvances.2022007824.

Steffen J, Ehrentraut S, Bank U, Biswas A, Figueiredo CA, Hölsken O, Düsedau HP, Dovhan V, Knop L, Thode J, Romero-Suárez S, Duarte CI, Gigley J, Romagnani C, Diefenbach A, Klose CSN, Schüler T, Dunay IR.
Type 1 innate lymphoid cells regulate the onset of Toxoplasma gondii-induced neuroinflammation.
Cell Rep. 2022 Mar 29;38(13):110564. doi: 10.1016/j.celrep.2022.110564.

Tettero JM, Al-Badri WKW, Ngai LL, Bachas C, Breems DA, van Elssen CHMJ, Fischer T, Gjertsen BT, van Gorkom GNY, Gradowska P, Greuter MJE, Griskevicius L, Juliusson G, Maertens J, Manz MG, Pabst T, Passweg J, Porkka K, Löwenberg B, Ossenkoppele GJ, Janssen JJWM, Cloos J.
Concordance in measurable residual disease result after first and second induction cycle in acute myeloid leukemia: An outcome- and cost-analysis.
Front Oncol. 2022 Oct 10;12:999822.

Thurm C, Reinhold A, Borucki K, Kahlfuss S, Feist E, Schreiber J, Reinhold D, Schraven B.
Homologous and Heterologous Anti-COVID-19 Vaccination Does Not Induce New-Onset Formation of Autoantibodies Typically Accompanying Lupus Erythematodes, Rheumatoid Arthritis, Celiac Disease and Antiphospholipid Syndrome.
Vaccines (Basel). 2022 Feb 18;10(2):333. doi: 10.3390/vaccines10020333.

Wang Y-H#, Noyer L#, Kahlfuss S#, Raphael D, Tao AJ, Kaufmann U, Zhu J, Mitchell-Flack M, Sidhu I, Zhou F, Vaeth M, Thomas PG, Saunders SP, Stauderman K, Curotto de Lafaille MA, Feske S.
Distinct roles of ORAI1 in T cell-mediated allergic airway inflammation and immunity to influenza A virus infection.
 Sci Adv. 2022 Oct 7;8(40):eabn6552. #Co-First authors

Letzte Änderung: 11.01.2024 - Ansprechpartner:

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