INSTITUT FÜR MOLEKULARE UND KLINISCHE IMMUNOLOGIE

Publikationen 2017

Bernhardt A, Fehr A, Brandt S, Jerchel S, Ballhause TM, Philipsen L, Stolze S, Geffers R, Weng H, Fischer KD, Isermann B, Brunner-Weinzierl MC, Batra A, Siegmund B, Zhu C, Lindquist JA, Mertens PR.
Inflammatory cell infiltration and resolution of kidney inflammation is orchestrated by the cold-shock protein Y-box binding protein-1.
Kidney Int. 2017 Jun 11. pii: S0085-2538(17)30240-5. doi: 10.1016/j.kint.2017.03.035. [Epub ahead of print]

Biswas A, French T, Düsedau HP, Mueller N, Riek-Burchardt M, Dudeck A, Bank U, Schüler T, Dunay IR.
Behavior of Neutrophil Granulocytes during Toxoplasma gondii Infection in the Central Nervous System.
Front Cell Infect Microbiol. 2017 Jun 21;7:259. doi: 10.3389/fcimb.2017.00259. eCollection 2017.

Boras M, Volmering S, Bokemeyer A, Rossaint J, Block H, Bardel B, Van Marck V, Heitplatz B, Kliche S, Reinhold A, Lowell C, Zarbock A.
Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions.
J Exp Med. 2017 Feb 9. pii: jem.20160647. doi: 10.1084/jem.20160647. [Epub ahead of print]

Busse M, Michler E, von Hoff F, Dobrowolny H, Hartig R, Frodl T, Busse S.
Alterations in the Peripheral Immune System in Dementia.
J Alzheimers Dis. 2017;58(4):1303-1313. doi: 10.3233/JAD-161304.

Chaudhry MZ, Kasmapour B, Plaza-Sirvent C, Bajagic M, Casalegno Garduño R, Borkner L, Lenac Roviš T, Scrima A, Jonjic S, Schmitz I, Cicin-Sain L.
UL36 Rescues Apoptosis Inhibition and In vivo Replication of a Chimeric MCMV Lacking the M36 Gene.
Front Cell Infect Microbiol. 2017 Jul 14;7:312. doi: 10.3389/fcimb.2017.00312. eCollection 2017. PubMed PMID: 28770171; PubMed Central PMCID: PMC5509765.

Cossarizza A et al.
Guidelines for the use of flow cytometry and cell sorting in immunological studies.
Eur J Immunol. 2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632.

Drube S, Grimlowski R, Deppermann C, Fröbel J, Kraft F, Andreas N, Stegner D, Dudeck J, Weber F, Rödiger M, Göpfert C, Drube J, Reich D, Nieswandt B, Dudeck A, Kamradt T.
The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis.
J Immunol. 2017 Sep 8. pii: ji1700556. doi: 10.4049/jimmunol.1700556. [Epub ahead of print]

Dudeck J, Medyukhina A, Fröbel J, Svensson CM, Kotrba J, Gerlach M, Gradtke AC, Schröder B, Speier S, Figge MT, Dudeck A.
Mast cells acquire MHCII from dendritic cells during skin inflammation.
J Exp Med. 2017 Oct 30. pii: jem.20160783. doi: 10.1084/jem.20160783. [Epub ahead of print]

Glodde N, Bald T, van den Boorn-Konijnenberg D, Nakamura K, O'Donnell JS, Szczepanski S, Brandes M, Eickhoff S, Das I, Shridhar N, Hinze D, Rogava M, van der Sluis TC, Ruotsalainen JJ, Gaffal E, Landsberg J, Ludwig KU, Wilhelm C, Riek-Burchardt M, Müller AJ, Gebhardt C, Scolyer RA, Long GV, Janzen V, Teng MWL, Kastenmüller W, Mazzone M, Smyth MJ, Tüting T, Hölzel M.
Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy.
Immunity. 2017 Oct 17;47(4):789-802.e9. doi: 10.1016/j.immuni.2017.09.012.

Gupta N, Edelmann B, Schnoeder TM, Saalfeld FC, Wolleschak D, Kliche S, Schraven B, Heidel FH, Fischer T.
JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1.
Leukemia. 2017 Feb 10. doi: 10.1038/leu.2017.26. [Epub ahead of print]

Hurrell BP, Beaumann M, Heyde S, Regli IB, Müller AJ, Tacchini-Cottier F.
Frontline Science: Leishmania mexicana amastigotes can replicate within neutrophils.
J Leukoc Biol. 2017 Aug 10. pii: jlb.4HI0417-158R. doi: 10.1189/jlb.4HI0417-158R. [Epub ahead of print]

Jalsrai A, Reinhold A, Becker A.
Ethanol Iris tenuifolia extract reduces brain damage in a mouse model of cerebral ischaemia.
Phytother Res. 2017 Nov 23. doi: 10.1002/ptr.5981 . [Epub ahead of print]

Körtvelyessy P, Bartels C, Galazky I, Ranft K, Sailer M, Schreiber SJ, Heinsius V, Reinhold D, Vielhaber S, Heinze HJ, Huchtemann T.
Der neurologische Boomerang nach Herpes-Simples-Enzephalitis.
Klin. Neurophysiol. 2017; 48: 44-45.

Kroner J, Kovtun A, Kemmler J, Messmann JJ, Strauss G, Seitz S, Schinke T, Amling M, Kotrba J, Froebel J, Dudeck J, Dudeck A, Ignatius A.
Mast Cells Are Critical Regulators of Bone Fracture-Induced Inflammation and Osteoclast Formation and Activity.
J Bone Miner Res. 2017 Aug 4. doi: 10.1002/jbmr.3234. [Epub ahead of print]

Mirdamadi Y, Bommhardt U, Goihl A, Guttek K, Zouboulis CC, Quist S, Gollnick H.
Insulin and Insulin-like growth factor-1 can activate the phosphoinositide-3-kinase /Akt/FoxO1 pathway in T cells in vitro.
Dermato-Endocrinology 2017, DOI: 10.1080/19381980.2017.1356518.

Mirdamadi Y, Thielitz A, Wiede A, Goihl A, Zouboulis CC, Bommhardt U, Quist S, Gollnick H.
Effects of Isotretinoin on the Phosphoinositide-3-kinase/Akt/FoxO1 Pathway and Molecular Functions of SZ95 Sebocytes In vitro.
J Clin Exp Dermatol Res 2017. doi:10.4172/2155-9554.1000399

Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B.
Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin like function.
Blood. 2017 Jul 7. pii: blood-2017-02-767921. doi: 10.1182/blood-2017-02-767921. [Epub ahead of print].

Niemz J, Kliche S, Pils MC, Morrison E, Manns A, Freund C, Crittenden JR, Graybiel AM, Galla M, Jänsch L, Huehn J.
The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells.
Eur J Microbiol Immunol (Bp). 2017 May 22;7(2):112-126. doi: 10.1556/1886.2017.00007. eCollection 2017 Jun.

Plaza-Sirvent C, Schuster M, Neumann Y, Heise U, Pils MC, Schulze-Osthoff K, Schmitz I.
c-FLIP Expression in Foxp3-Expressing Cells Is Essential for Survival of Regulatory T Cells and Prevention of Autoimmunity.
Cell Rep
. 2017 Jan 3;18(1):12-22.

Parzmair GP, Gereke M, Haberkorn O, Annemann M, Podlasly L, Kliche S, Reinhold A, Schraven B, Bruder D.
ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens.
J Leukoc Biol. 2017 Feb;101(2):407-419. doi: 10.1189/jlb.1A0216-090RR.

Philipsen L, Reddycherla AV, Hartig R, Gumz J, Kästle M, Kritikos A, Poltorak MP, Prokazov Y, Turbin E, Weber A, Zuschratter W, Schraven B, Simeoni L, Müller AJ.
De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling.
Sci Signal. 2017 Jan 17;10(462). pii: eaaf4736. doi: 10.1126/scisignal.aaf4736.

Quist SR, Heimburg A, Bank U, Mahnkopf D, Koch G, Gollnick H, Täger M, Ansorge S.
Preclinical pilot study monitoring topical drug penetration and dermal bioavailability of a peptidase inhibitor from different galenic formulations into pig dermis, using cutaneous microdialysis.
Clin Exp Dermatol. 2017 Aug;42(6):607-613. doi: 10.1111/ced.13105. Epub 2017 May 29.

Ranjan S, Goihl A, Kohli S, Gadi I, Pierau M, Shahzad K, Gupta D, Bock F, Wang H, Shaikh H, Kähne T, Reinhold D, Bank U, Zenclussen AC, Niemz J, Schnöder TM, Brunner-Weinzierl M, Fischer T, Kalinski T, Schraven B, Luft T, Huehn J, Naumann M, Heidel FH, Isermann B.
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.
Nat Commun. 2017 Aug 21;8(1):311. doi: 10.1038/s41467-017-00169-4.

Raza SA, Albrecht A, Çaliskan G, Müller B, Demiray YE, Ludewig S, Meis S, Faber N, Hartig R, Schraven B, Lessmann V, Schwegler H, Stork O.
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience.
Nat Commun. 2017 Aug 4;8(1):189. doi: 10.1038/s41467-017-00205-3.

Reissig K, Silver A, Hartig R, Schinlauer A, Walluscheck D, Guenther T, Siedentopf S, Ross J, Vo DK, Roessner A, Poehlmann-Nitsche A.
Chk1 Promotes DNA Damage Response Bypass following Oxidative Stress in a Model of Hydrogen Peroxide-Associated Ulcerative Colitis through JNK Inactivation and Chromatin Binding.
Oxid Med Cell Longev. 2017;2017:9303158. doi: 10.1155/2017/9303158. Epub 2017 Jun 7.

Röber N, Noß L, Goihl A, Reinhold D, Jahn J, de Laffolie J, Johannes W, Flemming GM, Roggenbuck D, Conrad K, Laass MW.
Autoantibodies Against Glycoprotein 2 Isoforms in Pediatric Patients with Inflammatory Bowel Disease.
Inflamm Bowel Dis. 2017 Sep;23(9):1624-1636. doi: 10.1097/MIB.0000000000001159.

Roggenbuck D, Goihl A, Hanack K, Holzlöhner P, Hentschel C, Veiczi M, Schierack P, Reinhold D, Schulz HU.
Serological diagnosis and prognosis of severe acute pancreatitis by analysis of serum glycoprotein 2.
Clin Chem Lab Med. 2017 May 1;55(6):854-864. doi: 10.1515/cclm-2016-0797.

Schneble N, Müller J, Kliche S, Bauer R, Wetzker R, Böhmer FD, Wang ZQ, Müller JP.
The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase.
Glia. 2017 Feb;65(2):416-428. doi: 10.1002/glia.23100.

Schuster M, Plaza-Sirvent C, Matthies AM, Heise U, Jeron A, Bruder D, Visekruna A, Huehn J, Schmitz I.
c-REL and IκB(NS) Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors.
J Immunol. 2017 Aug 1;199(3):920-930. doi: 10.4049/jimmunol.1600877. Epub 2017 Jun 26. PubMed PMID: 28652399.

Simeoni L.
Lck activation: puzzling the pieces together.
Oncotarget. 2017 Nov 7;8(61):102761-102762. doi: 10.18632/oncotarget.22309 . eCollection 2017 Nov 28.

Thurm C, Poltorak MP, Reimer E, Brinkmann MM, Leichert L, Schraven B, Simeoni L.
A highly conserved redox-active Mx(2)CWx(6)R motif regulates Zap70 stability and activity.
Oncotarget. 2017 Mar 22. doi: 10.18632/oncotarget.16486. [Epub ahead of print]

van Ham M, Teich R, Philipsen L, Niemz J, Amsberg N, Wissing J, Nimtz M, Gröbe L, Kliche S, Thiel N, Klawonn F, Hubo M, Jonuleit H, Reichardt P, Müller AJ, Huehn J, Jänsch L.
TCR signalling network organization at the immunological synapses of murine regulatory T cells.
Eur J Immunol. 2017 Aug 17. doi: 10.1002/eji.201747041. [Epub ahead of print]

von Arnim U, Röhl FW, Miehlke S, Jechorek D, Reinhold D, Wex T1, Malfertheiner P.
Clinical symptom tool that raises the index of suspicion for eosinophilic oesophagitis in adults and drives earlier biopsy for definitive diagnosis.
Aliment Pharmacol Ther. 2017 Feb;45(3):417-426. doi: 10.1111/apt.13869. Epub 2016 Nov 29.

von Arnim U, Röhl FW, Miehlke S, Jechorek D, Reinhold D, Wex T, Malfertheiner P.
Letter: multivariate clinical model for eosinophilic oesophagitis - is this generalisable to a general population? Authors' reply.
Aliment Pharmacol Ther. 2017 Mar;45(6):861. doi: 10.1111/apt.13967. No abstract available.

Volckmar J, Gereke M, Ebensen T, Riese P, Philipsen L, Lienenklaus S, Wohlleber D, Klopfleisch R, Stegemann-Koniszewski S, Müller AJ, Gruber AD, Knolle P, Guzman CA, Bruder D.
Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver.
Sci Rep. 2017 Mar 7;7:43985. doi: 10.1038/srep43985.

Witte A, Meineke B, Sticht J, Philipsen L, Kuropka B, Müller AJ, Freund C, Schraven B*, Kliche S*.
D120 and K152 within the PH domain of T cell adapter SKAP55 regulate plasma membrane targeting of SKAP55 and LFA-1 affinity modulation in human T lymphocytes.
Mol Cell Biol. 2017 Jan 4. pii: MCB.00509-16. doi: 10.1128/MCB.00509-16. [Epub ahead of print]
  * shared senior authorship

Zhao G, Wirth D, Schmitz I, Meyer-Hermann M.
A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance.
Nat Commun. 2017 Nov 8;8:1362. doi: 10.1038/s41467-017-01627-9.

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