Publikationen
2023
Cammann C, Kulla J, Wiebusch L, Walz C, Zhao F, Lowinus T, Topfstedt E, Mishra N, Henklein P, Bommhardt U, Bossaller L, Hagemeier C, Schadendorf D, Schmidt B, Paschen A, Seifert U.
Proteasome inhibition potentiates Kv1.3 potassium channel expression as therapeutic target in drug-sensitive and -resistant human melanoma cells.
Biomed Pharmacother. 2023 Oct 8;168:115635.
2022
Kästle M, Merten C, Hartig R, Plaza-Sirvent C, Schmitz I, Bommhardt U, Schraven B, Simeoni L.
Y192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection.
Int J Mol Sci. 2022 Jun 30;23(13):7271.
2020
Lowinus T, Bose T, Simeoni L, Schraven B, Bommhardt U.
Kv1.3 Potassium Channels: Promising Therapeutic Targets in Hematological Malignancies.
J Cell Signal. 2020, Volume 1, Issue 3
2019
Bommhardt U, Schraven B, Simeoni L.
Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy.
Int. J. Mol. Sci. 2019, 20(14), 3500
Lowinus T, Heidel FH, Bose T, Nimmagadda SC, Schnöder T, Cammann C, Schmitz I, Seifert U, Fischer T, Schraven B, Bommhardt U.
Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling.
Cell Commun Signal. 2019 Jan 16;17(1):5. doi: 10.1186/s12964-018-0317-z
2018
Rheinländer A, Schraven B, Bommhardt U.
CD45 in human physiology and clinical medicine.
Immunol Lett. 2018 Apr;196:22-32.
2017
Mirdamadi Y, Bommhardt U, Goihl A, Guttek K, Zouboulis CC, Quist S, Gollnick H.
Insulin and Insulin-like growth factor-1 can activate the phosphoinositide-3-kinase /Akt/FoxO1 pathway in T cells in vitro.
Dermatoendocrinol. 2017 Oct 4;9(1):e1356518.
2016
Lowinus T, Bose T, Busse S, Busse M, Reinhold D, Schraven B, Bommhardt UH.
Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness.
Oncotarget. 2016 Aug 16;7(33):53797-53807.
2015
Busse S, Steiner J, Glorius S, Dobrowolny H, Greiner-Bohl S, Mawrin C, Bommhardt U, Hartig R, Bogerts B, Busse M.
VGF expression by T lymphocytes in patients with Alzheimer's disease.
Oncotarget. 2015 Jun 20;6(17):14843-51.
Linker RA, Lee H, Flach A, Litke T, van den Brandt J, Reichardt HM, Lingner T, Bommhardt U, Sendtner M, Gold R, Flügel A, Lühder F.
Thymocyte-derived BDNF influences T cell maturation at the DN3/DN4 transition stage.
Eur J Immunol. 2015 May;45(5):1326-38.
Mirdamadi Y, Thielitz A, Wiede A, Goihl A, Papakonstantinou E, Hartig R, Zouboulis CC, Reinhold D, Simeoni L, Bommhardt U, Quist S, Gollnick H.
Insulin and Insulin-like growth factor-1 Can Modulate the Phosphoinositide-3-kinase / Akt/ FoxO1 Pathway in SZ95 Sebocytes in vitro.
Mol Cell Endocrinol. 2015 Nov 5;415:32-44.
2014
Busse S, Steiner J, Micheel J, Dobrowolny H, Mawrin C, Krause TJ, Adamaszek M, Bogerts B, Bommhardt U, Hartig R, Busse M.
Age-related increase of VGF-expression in T lymphocytes.
Aging (Albany NY). 2014 Jun;6(6):440-53.
Kahlfuß S1, Simma N, Mankiewicz J, Bose T, Lowinus T, Klein-Hessling S, Sprengel R, Schraven B, Heine M, Bommhardt U.
Immunosuppression by N-Methyl-D-Aspartate Receptor Antagonists Is Mediated through Inhibition of Kv1.3 and KCa3.1 Channels in T Cells.
Mol Cell Biol. 2014 Mar;34(5):820-31.
Simma N, Bose T, Kahlfuß S, Mankiewicz J, Lowinus T, Lühder F, Schüler T, Schraven B, Heine M, Bommhardt U.
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
Cell Commun Signal. 2014 Dec 5;12(1):75.
2013
Patra AK, Avots A, Zahedi RP, Schüler T, Sickmann A, Bommhardt U, Serfling E.
An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development.
Nat Immunol. 2013 Feb;14(2):127-35.
2012
Pierau M, Na SY, Simma N, Lowinus T, Marx A, Schraven B, Bommhardt UH.
Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function.
Eur J Immunol. 2012 Dec;42(12):3381-93.
2011
Bhattacharyya, J. Deb, A.K. Patra, D. Anh Thuy Pham, W.Chen, T. Benkert, M. Vaeth, F. Berberich-Siebelt, S. Klein-Hessling, E.D. Lamperti, J. Jellusova, A. Schweizer, L. Nitschke, E. Leich, A. Rosenwald, S. Engelmann, U. Bommhardt, A. Avots, M.R. Müller, E. Kondo & E. Serfling.
NFATc1 affects mouse splenic B cell function by controlling the calcineurin-NFAT signalling network
J Exp Med. 2011 Apr 11;208(4):823-39.
2010
Bommhardt U.
Hedgehog signalling in T-cell development: A non-redundant role for Gli1.
Cell Cycle. 2010 Nov 15;9(22):4433-4432.
2009
Pierau M, Engelmann S, Reinhold D, Lapp T, Schraven B, Bommhardt UH.
Protein Kinase B/Akt Signals Impair Th17 Differentiation and Support Natural Regulatory T Cell Function and Induced Regulatory T Cell Formation.
J Immunol. 2009 Nov 15;183(10):6124-34.
2008
Bekeredjian-Ding I, Doster A, Schiller M, Heyder P, Lorenz HM, Schraven B, Bommhardt U, Heeg K.
TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells.
J Immunol. 2008 Dec 15;181(12):8267-77.
2007
Bommhardt U.
Glis: novel modulators of TCR signaling?
Blood, 2007 May;109(9):3618-3619 .
Masse GX, Corcuff E, Decaluwe H, Bommhardt U, Lantz O, Buer J, Di Santo JP.
gamma(c) cytokines provide multiple homeostatic signals to naive CD4(+) T cells.
Eur J Immunol. 2007 Aug 8;37(9):2606-2616.
Saez-Rodriguez J, Simeoni L, Lindquist JA, Hemenway R, Bommhardt U, Arndt B, Haus UU, Weismantel R, Gilles ED, Klamt S, Schraven B.
A Logical Model Provides Insights into T Cell Receptor Signaling.
PLoS Comput Biol. 2007 Aug 24;3(8):e163.
2006
Patra AK, Drewes T, Engelmann S, Chuvpilo S, Kishi H, Hünig T, Serfling E, Bommhardt UH.
PKB rescues calcineurin/NFAT-induced arrest of Rag expression and pre-T cell differentiation.
J Immunol. 2006 Oct 1;177(7):4567-76.
2004
Bommhardt U, Beyer M, Hünig T, Reichardt H.
Molecular and cellular mechanisms of T cell development.
Cell Mol Life Sci. 2004 Feb;61(3):263-80. Review
Bommhardt U, Chang KC, Swanson PE, Wagner TH, Tinsley KW, Karl IE, Hotchkiss RS.
Akt decreases lymphocyte apoptosis and improves survival in sepsis.
J. Immunol. 2004 Jun 15;172(12):7583-91.
Patra AK, Na SY, Bommhardt U.
Active protein kinase B regulates TCR responsiveness by modulating cytoplasmic-nuclear localization of NFAT and NF- kappa B proteins.
J. Immunol. 2004 15;172(8):4812-20.