2009

Ansorge S, Bank U, Heimburg A, Helmuth M, Koch G, Tadje J, Lendeckel U, Wolke C, Neubert K, Faust J, Fuchs P, Reinhold D, Thielitz A, Täger M.
Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions.
Clin Chem Lab Med. 2009;47(3):253-61.

Conrad K, Ittenson A, Reinhold D, Fischer R, Roggenbuck D, Büttner T, Bosselmann HP, Steinbach J, Schröder HE, Schößler W.
High sensitive detection of double-stranded DNA autoantibodies by a modified Crithidia luciliae immunofluorescence test (CLIFT).
Ann N Y Acad Sci. 2009 Sep;1173:180-5.

Grüngreiff K, Hebell T, Gutensohn K, Reinhold A, Reinhold D.
Plasma concentrations of zinc, copper, interleukin-6 and interferon-gamma, and plasma dipeptidylpeptidase IV activity in chronic hepatitis C.
Mol Med Rep 2009 2:63-68.

Kühlmann UC, Chwieralski CE, Reinhold D, Welte T, Bühling F.
Radiation-induced matrix production of lung fibroblasts is regulated by interleukin-8.
Int J Radiat Biol. 2009 Feb;85(2):138-43.

Kühlmann UC, Chwieralski CE, van den Brule S, Röcken C, Reinhold D, Welte T, Bühling F.
Modulation of cytokine production and silica-induced lung fibrosis by inhibitors of aminopeptidase N and of dipeptidyl peptidase-IV-related proteases.
Life Sci. 2009 Jan 2;84(1-2):1-11.

Pierau M, Engelmann S, Reinhold D, Lapp T, Schraven B, Bommhardt U.
Protein Kinase B/Akt Signals Impair Th17 Differentiation and Support Natural Regulatory T Cell Function and Induced Regulatory T Cell Formation.
J Immunol. 2009 Nov 15;183(10):6124-34.

Reinhold A, Reimann S, Reinhold D, Schraven B, Togni M.
Expression of SKAP-HOM in DCs is required for an optimal immune response in vivo.
J Leukoc Biol. 2009 Jul;86(1):61-71. download pdf

Reinhold D, Goihl A, Wrenger S, Reinhold A, Kühlmann UC, Faust J, Neubert K, Thielitz A, Brocke S, Täger M, Ansorge S, Bank U.
Review: Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Clin Chem Lab Med. 2009;47(3):268-74.

Rißmann A, Pieper S, Adams I, Brune T, Wiemann D, Reinhold D.
Increased blood plasma concentrations of TGF-β1 and TGF-β2 after treatment with Intravenous Immunoglobulins in childhood autoimmune diseases.
Pediatr Allergy Immunol. 2009 20:207-303.

Roggenbuck D, Büttner T, Hoffmann L, Schmechta H, Reinhold D, Conrad K.
High-sensitive detection of autoantibodies against proteinase-3 by a novel third-generation enzyme-linked immunosorbent assay.
Ann N Y Acad Sci. 2009 Sep;1173:41-6.

Roggenbuck D, Hausdorf G, Martinez-Gamboa L, Feist E, Büttner T, Reinhold D, Jungblut PR, Porstmann T, Laass MW, Büning C, Henker J, Conrad K.
Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn's disease.
Gut. 2009 Dec;58(12):1620-8.

2008

Reinhold D, Bank U, Täger M, Ansorge S, Wrenger S, Thielitz A, Lendeckel U, Faust J, Neubert K, Brocke S.
DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis.
Front Biosci. 2008 Jan 1;13:2356-63.

Thielitz A, Ansorge S, Bank U, Täger M, Wrenger S, Gollnick H, Reinhold D.
The ectopeptidases dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN) and their related enzymes as possible targets in the treatment of skin diseases.
Front Biosci. 2008 Jan 1;13:2364-75.

Thielitz A, Vetter RW, Schultze B, Wrenger S, Simeoni L, Ansorge S, Neubert K, Faust J, Lindenlaub P, Gollnick HP, Reinhold D.
Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloid-derived skin fibroblasts.
J Invest Dermatol. 2008 Apr;128(4):855-66.

Wrenger S, Faust J, Mrestani-Klaus C, Brandt W, Thielitz A, Neubert K, Reinhold D.
Non-substrate peptides influencing dipeptidyl peptidase IV/CD26 activity and immune cell function.
Front Biosci. 2008 13, 3194-201.

2007

Bank U, Tadje J, Täger M, Wolke C, Bukowska A, Ittenson A, Reinhold D, Helmuth M, Ansorge S, Shakespeare A, Vieth M, Malfertheiner P, Naumann M, Lendeckel U.
Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-beta1 and ameliorates acute colitis in mice.
Int J Mol Med. 2007 Oct;20(4):483-92. download pdf

Conrad K, Schneider H, Ziemssen T, Talaska T, Reinhold D, Humbel RL, Roggenbuck D.
A new line immunoassay for the multiparametric detection of antiganglioside autoantibodies in patients with autoimmune peripheral neuropathies.
Ann N Y Acad Sci. 2007 Aug;1109:256-64.

Gregoire C, Simova S, Wang Y, Sansoni A, Richelme S, Schmidt-Giese A, Simeoni L, Angelisova P, Reinhold D, Schraven B, Horejsi V, Malissen B, Malissen M.
Deletion of the LIME adaptor protein minimally affects T and B cell development and function.
Eur J Immunol. 2007 Nov;37(11):3259-69.

Preller V, Gerber A, Wrenger S, Togni M, Marguet D, Tadje J, Lendeckel U, Röcken C, Faust J, Neubert K, Schraven B, Martin R, Ansorge S, Brocke S, Reinhold D.
TGF-β1-mediated control of CNS inflammation and autoimmunity through the inhibitory receptor CD26.
J Immunol. 2007 Apr 1;178(7):4632-40.

Reinhold D, Biton A, Goihl A, Pieper S, Lendeckel U, Faust J, Neubert K, Bank U, Tager M, Ansorge S, Brocke S.
Dual Inhibition of Dipeptidyl Peptidase IV and Aminopeptidase N Suppresses Inflammatory Immune Responses.
Ann N Y Acad Sci. 2007 Sep;1110:402-9.

2006

Bank U, Heimburg A, Helmuth M, Stefin S, Lendeckel U, Reinhold D, Faust J, Fuchs P, Sens B, Neubert K, Täger M, Ansorge S.
Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13) - A novel approach for the treatment of inflammatory bowel disease.
Int Immunopharmacol. 2006 Dec 20;6(13-14):1925-34.

Bank U, Tadje J, Helmuth M, Stefin S, Tager M, Wolke C, Wischeropp A, Ittenson A, Reinhold D, Ansorge S, Lendeckel U.
Dipeptidylpeptidase IV (DPIV) and alanyl-aminopeptidases (AAPs) as a new target complex for treatment of autoimmune and inflammatory diseases-proof of concept in a mouse model of colitis.
Adv Exp Med Biol. 2006;575:143-53.

Biton A, Bank U, Tager M, Ansorge S, Reinhold D, Lendecke U, Brocke S.
Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation.
Adv Exp Med Biol. 2006;575:177-86.

Kölsch U, Arndt B, Reinhold D, Lindquist JA, Jüling N, Kliche S, Pfeffer K, Bruyns E, Schraven B, Simeoni L.
Normal T cell development and immune functions in TRIM-deficient mice.
Mol Cell Biol. 2006 May;26(9):3639-48.

Preller V, Gerber A, Togni M, Wrenger S, Schraven B, Rocken C, Marguet D, Ansorge S, Brocke S, Reinhold D.
CD26/DP IV in T cell activation and autoimmunity.
Adv Exp Med Biol. 2006;575:187-93.

Reinhold D, Biton A, Pieper S, Lendeckel U, Faust J, Neubert K, Bank U, Täger M, Ansorge S, Brocke S.
Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation.
Int Immunopharmacol. 2006 Dec 20;6(13-14):1935-42.

Schneider T, Sailer M, Ansorge S, Firsching R, Reinhold D.
Increased concentrations of transforming growth factor beta1 and beta2 in the plasma of patients with glioblastoma.
J Neurooncol. 2006 Aug;79(1):61-5.

Thielitz A, Reinhold D, Vetter R, Wiswedel I, Lendeckel U, Bank U, Helmuth M, Neubert K, Faust J, Hartig R, Kähne T, Wrenger S, Zouboulis CC, Ansorge S, Gollnick H.
Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) target major pathogenetic steps in acne initiation.
J Invest Dermatol, 2006 ;127:1042-51.

Thielitz A, Reinhold D, Vetter R, Lendeckel U, Kähne T, Bank U, Helmuth M, Neubert K, Faust J, Hartig R, Wrenger S, Zouboulis CC, Ansorge S, Gollnick H.
Possible role of DP IV inhibitors in acne therapy.
Adv Exp Med Biol. 2006;575:163-7.

Wrenger S, Guth B, Schultze B, Hoffmann T, Friedrich D, Kähne T, Faust J, Neubert K, Reinhold D.
Expression of dipeptidyl peptidase IV-like enzymes in human peripheral blood mononuclear cells.
Adv Exp Med Biol. 2006;575:87-91.

Wrenger S, Faust J, Friedrich D, Hoffmann T, Hartig R, Lendeckel U, Kähne T, Thielitz A, Neubert K, Reinhold D.
Attractin, a dipeptidyl peptidase IV/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function.
J Leukoc Biol. 2006 Sep;80(3):621-9.

2005

Grüngreiff K, Reinhold D.
Liver cirrhosis and "liver" diabetes mellitus are linked by zinc deficiency.
Med Hypotheses. 2005;64(2):316-7.

Reinhold D, Kähne T, Steinbrecher A, Gerber A, Preller V, Gornickel B, Wrenger S, Ansorge S, Brocke S.
The role of dipeptidyl peptidase IV (DP IV, CD26) in T cell activation and multiple sclerosis.
Signal Transduction 2005, 5, 258.

Schmidt-Lucke C, Belgore F, Reinhold D, Ansorge S, Klein HU, Schmidt-Lucke JA, Lip GY.
Soluble vascular endothelial growth factor, soluble VEGF receptor Flt-1 and endothelial function in healthy smokers.
Int J Cardiol. 2005 Apr 20;100(2):207-12.

Simeoni L, Posevitz V, Kölsch U, Meinert I, Bruyns E, Pfeffer K, Reinhold D, Schraven B.
The transmembrane adapter protein SIT regulates thymic development and peripheral T cell functions.
Mol Cell Biol. 2005 Sep;25(17):7557-68.

Simeoni L, Smida M, Posevitz V, Schraven B, Lindquist JA.
Right time, right place: the organization of membrane proximal signaling.
Semin Immunol. 2005;17(1):35-49.

Togni M, Swanson KD, Reimann S, Kliche S, Pearce AC, Simeoni L, Reinhold D, Wienands J, Neel BG, Schraven B, Gerber A.
Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.
Mol Cell Biol. 2005 Sep;25(18):8052-63.

2004

Brune T, Masjoshusmann K, Reinhold D, Steinhardt J, Exeler R, Volleth M, Louwen F.
The imbalanced mixed lymphocyte reaction between maternal and fetal lymphocytes as well as between the lymphocytes of adult children and their parents is mediated by activated CD8+ T cells.
Am J Reprod Immunol. 2004 Oct;52(4):284-9.

Reinhold D, Perlov E, Schrecke K, Kekow J, Brune T, Sailer M.
Increased blood plasma concentrations of TGF-beta isoforms after treatment with intravenous immunoglobulins (IVIG) in patients with multiple sclerosis.
J Neuroimmunol. 2004 Jul;152(1-2):191-4.

Thielitz A, Bukowska A, Wolke C, Vetter R, Lendeckel U, Wrenger S, Hashimoto Y, Ansorge S, Gollnick H, Reinhold D.
Identification of extra- and intracellular alanyl aminopeptidases as new targets to modulate keratinocyte growth and differentiation.
Biochem Biophys Res Commun. 2004 Sep 3;321(4):795-801.