Publications
2024
Lenk L, Baccelli I, Laqua A, Heymann J, Reimer C, Dietterle A, Winterberg D, Mary C, Corallo F, Taurelle J, Narbeburu E, Neyton SL, Déramé M, Pengam S, Vogiatzi F, Bornhauser B, Bourquin JP, Raffel S, Dovhan V, Schüler T, Escherich G, den Boer ML, Boer JM, Wessels W, Peipp M, Alten J, Antić Ž, Bergmann AK, Schrappe M, Cario G, Brüggemann M, Poirier N, Schewe DM.
The IL-7R antagonist Lusvertikimab reduces leukemic burden in xenograft-ALL via antibody-dependent cellular phagocytosis.
Blood. 2024 Mar 22:blood.2023021088. doi: 10.1182/blood.2023021088.
2022
Cammann C, Israel N, Frentzel S, Jeron A, Topfstedt E, Schüler T, Simeoni L, Zenker M, Fehling HJ, Schraven B, Bruder D, Seifert U.
T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation.
Front Immunol. 2022 Aug 2;13:958616. doi: 10.3389/fimmu.2022.958616.
Figueiredo CA, Steffen J, Morton L, Arumugam S, Liesenfeld O, Deli MA, Kröger A, Schüler T, Dunay IR.
Immune response and pathogen invasion at the choroid plexus in the onset of cerebral toxoplasmosis.
J Neuroinflammation. 2022 Jan 13;19(1):17. doi: 10.1186/s12974-021-02370-1.
French T, Steffen J, Glas A, Osbelt L, Strowig T, Schott BH, Schüler T, Dunay IR.
Persisting Microbiota and Neuronal Imbalance Following T. gondii Infection Reliant on the Infection Route.
Front Immunol. 2022 Jul 11;13:920658. doi: 10.3389/fimmu.2022.920658.
Gelmez E, Lehr K, Kershaw O, Frentzel S, Vilchez-Vargas R, Bank U, Link A, Schüler T, Jeron A, Bruder D.
Characterization of Maladaptive Processes in Acute, Chronic and Remission Phases of Experimental Colitis in C57BL/6 Mice.
Biomedicines. 2022 Aug 5;10(8):1903. doi: 10.3390/biomedicines10081903.
Knop L, Spanier J, Larsen PK, Witte A, Bank U, Dunay IR, Kalinke U, Schüler T.
IFNAR signaling in fibroblastic reticular cells can modulate CD8+ memory fate decision.
Eur J Immunol. 2022 Apr 1. doi: 10.1002/eji.202149760. Online ahead of print.
Lenk L, Winterberg D, Vogiatzi F, Laqua A, Spory L, Mayar A, Dietterle A, Münch G, Vokuhl C, Richter J, Polson AG, Schüler T, Kahlert UD, Peipp M, Valerius T, Schrappe M, Cario G, Jumaa H, Hobeika E, Brüggemann M, Alsadeq A, Schewe DM.
Preclinical Evidence for the Efficacy of CD79b Immunotherapy in B-cell Precursor Acute Lymphoblastic Leukemia.
Hemasphere. 2022 Jul 15;6(8):e754.
Steffen J, Ehrentraut S, Bank U, Biswas A, Figueiredo CA, Hölsken O, Düsedau HP, Dovhan V, Knop L, Thode J, Romero-Suárez S, Duarte CI, Gigley J, Romagnani C, Diefenbach A, Klose CSN, Schüler T, Dunay IR.
Type 1 innate lymphoid cells regulate the onset of Toxoplasma gondii-induced neuroinflammation.
Cell Rep. 2022 Mar 29;38(13):110564. doi: 10.1016/j.celrep.2022.110564.
2021
French T, Israel N, Düsedau HP, Tersteegen A, Steffen J, Cammann C, Topfstedt E, Dieterich D, Schüler T, Seifert U, Dunay IR.
The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis.
Front Immunol. 2021 Apr 21;12:619465. doi: 10.3389/fimmu.2021.619465. eCollection 20
2020
Bank U, Deiser K, Plaza-Sirvent C, Osbelt L, Witte A, Knop L, Labrenz R, Jänsch R, Richter F, Biswas A, Zenclussen AC, Vivier E, Romagnani C, Kühl AA, Dunay IR, Strowig T, Schmitz I, Schüler T.
c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice.
Nat Commun. 2020 Feb 26;11(1):1056. doi: 10.1038/s41467-020-14782-3.
Knop L, Deiser K, Bank U, Witte A, Mohr J, Philipsen L, Fehling HJ, Müller AJ, Kalinke U, Schüler T.
IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival.
Eur J Immunol. 2020 Feb 11. doi: 10.1002/eji.201948368. [Epub ahead of print]
2019
Cossarizza A, et.al.
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
Eur J Immunol. 2019 Oct;49(10):1457-1973. doi: 10.1002/eji.201970107.
French T, Düsedau HP, Steffen J, Biswas A, Ahmed N, Hartmann S, Schüler T, Schott BH, Dunay IR.
Neuronal impairment following chronic Toxoplasma gondii infection is aggravated by intestinal nematode challenge in an IFN-γ-dependent manner.
J Neuroinflammation. 2019 Jul 29;16(1):159. doi: 10.1186/s12974-019-1539-8.
De Bortoli F, Neumann A, Kotte A, Timmermann B, Schüler T, Wahl MC, Loll B, Heyd F.
Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39.
Nucleic Acids Res. 2019 Apr 5. pii: gkz243. doi: 10.1093/nar/gkz243 [Epub ahead of print]
Knop L, Frommer C, Stoycheva D, Dieser K, Kalinke U, Blankenstein T, Kammertoens T, Dunay IR, Schüler T.
Interferon-γ Receptor Signaling in Dendritic Cells Restrains Spontaneous Proliferation of CD4+ T Cells in Chronic Lymphopenic Mice.
Front. Immunol., 07 February 2019 | https://doi.org/10.3389/fimmu.2019.00140
2018
Meyer N, Schüler T, Zenclussen AC.
High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo.
J Vis Exp. 2018 Nov 8;(141).
Meyer N, Schüler T, Zenclussen AC.
Simultaneous Ablation of Uterine Natural Killer Cells and Uterine Mast Cells in Mice Leads to Poor Vascularization and Abnormal Doppler Measurements That Compromise Fetal Well-being.
Front Immunol. 2018 Jan 8;8:1913. doi: 10.3389/fimmu.2017.01913 . eCollection 2017.
2017
Cossarizza, A. et al.
Guidelines for the use of flow cytometry and cell sorting in immunological studies. Eur J Immunol.
2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632
Ranjan S, Goihl A, Kohli S, Gadi I, Pierau M, Shahzad K, Gupta D, Bock F, Wang H, Shaikh H, Kähne T, Reinhold D, Bank U, Zenclussen AC, Niemz J, Schnöder TM, Brunner-Weinzierl M, Fischer T, Kalinski T, Schraven B, Luft T, Huehn J, Naumann M, Heidel FH, Isermann B.
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.
Nat Commun. 2017 Aug 21;8(1):311. doi: 10.1038/s41467-017-00169-4.
Biswas A, French T, Düsedau HP, Mueller N, Riek-Burchardt M, Dudeck A, Bank U, Schüler T, Dunay IR.
Behavior of Neutrophil Granulocytes during Toxoplasma gondii Infection in the Central Nervous System.
Front Cell Infect Microbiol. 2017 Jun 21;7:259. doi: 10.3389/fcimb.2017.00259. eCollection 2017.
Witte A, Meineke B, Sticht J, Philipsen L, Kuropka B, Müller AJ, Freund C, Schraven B, Kliche S.
D120 and K152 within the PH domain of T cell adapter SKAP55 regulate plasma membrane targeting of SKAP55 and LFA-1 affinity modulation in human T lymphocytes.
Mol Cell Biol. 2017 Jan 4. pii: MCB.00509-16. doi: 10.1128/MCB.00509-16. [Epub ahead of print]
2016
Deiser K, Stoycheva D, Bank U, Blankenstein T, Schüler T.
Interleukin-7 Modulates Anti-Tumor CD8+ T Cell Responses via Its Action on Host Cells.
PLoS One. 2016 Jul 22;11(7):e0159690. doi: 10.1371/journal.pone.0159690. eCollection 2016.
Bank U, Deiser K, Finke D, Hämmerling GJ, Arnold B, Schüler T.
Cutting Edge: Innate Lymphoid Cells Suppress Homeostatic T Cell Expansion in Neonatal Mice.
J Immunol. 2016 May 1;196(9):3532-6. doi: 10.4049/jimmunol.1501643. Epub 2016 Mar 16.
2015
Stoycheva D, Deiser K, Stärck L, Nishanth G, Schlüter D, Uckert W, Schüler T.
IFN-γ Regulates CD8+ Memory T Cell Differentiation and Survival in Response to Weak, but Not Strong, TCR Signals.
J Immunol. 2015 Jan 15;194(2):553-9. doi: 10.4049/jimmunol.1402058. Epub 2014 Dec 5.
2014
Simma N, Bose T, Kahlfuß S, Mankiewicz J, Lowinus T, Lühder F, Schüler T, Schraven B, Heine M, Bommhardt U.
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
Cell Commun Signal. 2014 Dec 5;12(1):75.
2013
Patra AK, Avots A, Zahedi RP, Schüler T, Sickmann A, Bommhardt U, Serfling E.
An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development.
Nat Immunol. 2013 Feb;14(2):127-35. doi: 10.1038/ni.2507. Epub 2012 Dec 23.
2012
Shalapour S, Deiser K, Kühl AA, Glauben R, Krug SM, Fischer A, Sercan O, Chappaz S, Bereswill S, Heimesaat MM, Loddenkemper C, Fromm M, Finke D, Hämmerling GJ, Arnold B, Siegmund B, Schüler T.
Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis.
PLoS One. 2012;7(2):e31939. Epub 2012 Feb 27.
see also Prof. Schüler's previous affiliations