2022

Cammann C, Israel N, Frentzel S, Jeron A, Topfstedt E, Schüler T, Simeoni L, Zenker M, Fehling HJ, Schraven B, Bruder D, Seifert U.
T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation.
Front Immunol. 2022 Aug 2;13:958616. doi: 10.3389/fimmu.2022.958616.

Kästle M, Merten C, Hartig R, Plaza-Sirvent C, Schmitz I, Bommhardt U, Schraven B, Simeoni L.
Y192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection.
Int J Mol Sci. 2022 Jun 30;23(13):7271.

Schultz A, Schnurra M, El-Bizri A, Woessner NM, Hartmann S, Hartig R, Minguet S, Schraven B, Simeoni L.
A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling.
Cells. 2022 Sep 1;11(17):2723.

2021

Thurm C, Schraven B, Kahlfuss S.
ABC Transporters in T Cell-Mediated Physiological and Pathological Immune Responses.
Int J Mol Sci. 2021 Aug 25;22(17):9186. doi: 10.3390/ijms22179186.

Voss L, Guttek K, Reddig A, Reinhold A, Voss M, Simeoni L, Schraven B, Reinhold D.
Pitavastatin Is a Highly Potent Inhibitor of T-Cell Proliferation.
Pharmaceuticals (Basel). 2021 Jul 27;14(8):727. doi: 10.3390/ph14080727

2020

Baumann T, Dunkel A, Schmid C, Schmitt S, Hiltensperger M, Lohr K, Laketa V, Donakonda S, Ahting U, Lorenz-Depiereux B, Heil JE, Schredelseker J, Simeoni L, Fecher C, Körber N, Bauer T, Hüser N, Hartmann D, Laschinger M, Eyerich K, Eyerich S, Anton M, Streeter M, Wang T, Schraven B, Spiegel D, Assaad F, Misgeld T, Zischka H, Murray PJ, Heine A, Heikenwälder M, Korn T, Dawid C, Hofmann T, Knolle PA, Höchst B.
Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal.
Nat Immunol. 2020 May;21(5):555-566. doi: 10.1038/s41590-020-0666-9. Epub 2020 Apr 23.

Kowallik S, Kritikos A, Kästle M, Thurm C, Schraven B, Simeoni L.
The Activity and Stability of p56Lck and TCR Signaling Do Not Depend on the Co-Chaperone Cdc37.
Int J Mol Sci. 2020 Dec 24;22(1):126. doi: 10.3390/ijms22010126.

Kästle M, Merten C, Hartig R, Kaehne T, Liaunardy-Jopeace A, Woessner NM, Schamel WW, James J, Minguet S, Simeoni L, Schraven B.
Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56Lck regulates T-cell activation independently of Lck/CD45 interactions.
Cell Commun Signal. 2020 Nov 23;18(1):183. doi: 10.1186/s12964-020-00673-z. PMID: 33225946

Lowinus T, Bose T, Simeoni L, Schraven B, Bommhardt U.
Kv1.3 Potassium Channels: Promising Therapeutic Targets in Hematological Malignancies.
J Cell Signal. 2020, Volume 1, Issue 3

2019

Comito G, Iscaro A, Bacci M, Morandi A, Ippolito L, Parri M1, Montagnani I, Raspollini MR, Serni S, Simeoni L, Giannoni E, Chiarugi P.
Lactate modulates CD4+ T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis.
Oncogene. 2019 May;38(19):3681-3695. doi: 10.1038/s41388-019-0688-7. Epub 2019 Jan 21.

2018

Lacher SM, Thurm C, Distler U, Mohebiany AN, Israel N, Kitic M, Ebering A, Tang Y, Klein M, Wabnitz GH, Wanke F, Samstag Y, Bopp T, Kurschus FC, Simeoni L, Tenzer S, Waisman A.
NF-κB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling.
J Autoimmun. 2018 Jul 27. pii: S0896-8411(18)30180-X. doi: 10.1016/j.jaut.2018.07.017 . [Epub ahead of print]

2017

Philipsen L, Reddycherla AV, Hartig R, Gumz J, Kästle M, Kritikos A, Poltorak MP, Prokazov Y, Turbin E, Weber A, Zuschratter W, Schraven B, Simeoni L, Müller AJ.
De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling.
Sci Signal. 2017 Jan 17;10(462). pii: eaaf4736. doi: 10.1126/scisignal.aaf4736.

Simeoni L.
Lck activation: puzzling the pieces together.
Oncotarget. 2017 Nov 7;8(61):102761-102762. doi: 10.18632/oncotarget.22309 . eCollection 2017 Nov 28.

Thurm C, Poltorak MP, Reimer E, Brinkmann MM, Leichert L, Schraven B, Simeoni L.
A highly conserved redox-active Mx(2)CWx(6)R motif regulates Zap70 stability and activity.
Oncotarget. 2017 Mar 22. doi: 10.18632/oncotarget.16486. [Epub ahead of print]

2016

Cammann C, Rath A, Reichl U, Lingel H, Brunner-Weinzierl M, Simeoni L, Schraven B, Lindquist JA.
Early changes in the metabolic profile of activated CD8(+) T cells.
BMC Cell Biol. 2016 Jul 7;17(1):28. doi: 10.1186/s12860-016-0104-x.

Simeoni L, Thurm C, Kritikos A, Linkermann A.
Redox homeostasis, T cells and kidney diseases: three faces in the dark.
Clin Kidney J. 2016 Feb;9(1):1-10. doi: 10.1093/ckj/sfv135. Epub 2015 Dec 13.

2015

Belikov AV, Schraven B, Simeoni L.
T cells and reactive oxygen species.
J Biomed Sci. 2015 Oct 15;22:85. doi: 10.1186/s12929-015-0194-3. 

Mirdamadi Y, Thielitz A, Wiede A, Goihl A, Papakonstantinou E, Hartig R, Zouboulis CC, Reinhold D, Simeoni L, Bommhardt U, Quist S, Gollnick H.
Insulin and Insulin-like growth factor-1 Can Modulate the Phosphoinositide-3-kinase / Akt/ FoxO1 Pathway in SZ95 Sebocytes in vitro.
Mol Cell Endocrinol. 2015 Aug 6. pii: S0303-7207(15)30041-1. doi: 10.1016/j.mce.2015.08.001. [Epub ahead of print]

Reddycherla AV, Meinert I, Reinhold A, Reinhold D, Schraven B, Simeoni L.
miR-20a Inhibits TCR-Mediated Signaling and Cytokine Production in Human Naïve CD4+ T Cells.
PLoS One. 2015 Apr 17;10(4):e0125311. doi: 10.1371/journal.pone.0125311. eCollection 2015. 

2014

Belikov AV, Schraven B, Simeoni L.
TCR-triggered extracellular superoxide production is not required for T-cell activation.
Cell Commun Signal. 2014 Aug 1;12:50. doi: 10.1186/s12964-014-0050-1.

Harder T, Guttek K, Philipsen L, Simeoni L, Schraven B, Reinhold D.
Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation.
Cell Commun Signal. 2014 Dec 8;12(1):74. doi: 10.1186/s12964-014-0074-6.

Poltorak M, Meinert I, Stone JC, Schraven B, Simeoni L.
Sos1 regulates sustained TCR-mediated Erk activation.
Eur J Immunol. 2014 May;44(5):1535-40. doi: 10.1002/eji.201344046. Epub 2014 Feb 20.

2013

Arndt B, Poltorak M, Kowtharapu BS, Reichardt P, Philipsen L, Lindquist JA, Schraven B, Simeoni L.
Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation.
J Immunol Methods. 2013 Jan 31;387(1-2):276-83. doi: 10.1016/j.jim.2012.11.006. Epub 2012 Nov 22.

Arndt B, Kalinski T, Reinhold D, Thielitz A, Roessner A, Schraven B, Simeoni L.
Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX.
J Leukoc Biol. 2013 Mar;93(3):353-62. doi: 10.1189/jlb.0312152. Epub 2013 Jan 10.

Poltorak M, Arndt B, Kowtharapu BS, Reddycherla AV, Witte V, Lindquist JA, Schraven B, Simeoni L.
TCR activation kinetics and feedback regulation in primary human T cells.
Cell Commun Signal. 2013 Jan 14;11:4. doi: 10.1186/1478-811X-11-4.

Smida M, Cammann C, Gurbiel S, Kerstin N, Lingel H, Lindquist S, Simeoni L, Brunner-Weinzierl MC, Suchanek M, Schraven B, Lindquist JA.
PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells.
Cell Commun Signal. 2013 Apr 19;11(1):28. doi: 10.1186/1478-811X-11-28.

Stirnweiss A, Hartig R, Gieseler S, Lindquist JA, Reichardt P, Philipsen L, Simeoni L, Poltorak M, Merten C, Zuschratter W, Prokazov Y, Paster W, Stockinger H, Harder T, Gunzer M, Schraven B.
T cell activation results in conformational changes in the Src family kinase Lck to induce its activation.
Sci Signal. 2013 Feb 19;6(263):ra13. doi: 10.1126/scisignal.2003607.

2012

Warnecke N, Poltorak M, Kowtharapu BS, Arndt B, Stone JC, Schraven B, Simeoni L.
TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.
MBO Rep. 2012 Apr;13(4):386-91.

2011

Arndt B, Krieger T, Kalinski T, Thielitz A, Reinhold D, Roessner A, Schraven B, Simeoni L.
The Transmembrane Adaptor Protein SIT Inhibits TCR-Mediated Signaling.
PLoS One. 2011;6(9):e23761. Epub 2011 Sep 21.