2024

Bertazzon M, Hurtado-Pico A, Plaza-Sirvent C, Schuster M, Preußner M, Kuropka B, Liu F, Kirsten AZA, Schmitt XJ, König B, Álvaro-Benito M, Abualrous ET, Albert GI, Kliche S, Heyd F, Schmitz I, Freund C.
The nuclear GYF protein CD2BP2/U5-52K is required for T cell homeostasis.
Front Immunol. 2024 Sep 6;15:1415839. doi: 10.3389/fimmu.2024.1415839. eCollection 2024.

2021

Dadwal N, Mix C, Reinhold A, Witte A, Freund C, Schraven B, Kliche S.
The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events.
Front Immunol. 2021 Jul 6;12:703534. doi: 10.3389/fimmu.2021.703534. eCollection 2021.

Tripathi K, Demiray YE, Kliche S, Jing L, Hazra S, Hazra JD, Richter-Levin G, Stork O.
Reducing glutamic acid decarboxylase in the dorsal dentate gyrus attenuates juvenile stress induced emotional and cognitive deficits.
Neurobiol Stress. 2021 Jun 2;15:100350. doi: 10.1016/j.ynstr.2021.100350.

2020

Morrison E, Wegner T, Zucchetti AE, Álvaro-Benito M, Zheng A, Kliche S, Krause E, Brügger B, Hivroz C, Freund C.
Dynamic palmitoylation events following T-cell receptor signaling.
Commun Biol. 2020 Jul 10;3(1):368. doi: 10.1038/s42003-020-1063-5.

2019

Düsedau HP, Kleveman J, Figueiredo CA, Biswas A, Steffen J, Kliche S, Haak S, Zagrebelsky M, Korte M, Dunay IR.
p75NTR regulates brain mononuclear cell function and neuronal structure in Toxoplasma infection-induced neuroinflammation.
Glia. 2019 Jan;67(1):193-211.

Rudolph J, Meinke C, Voss M, Guttek K, Kliche S, Reinhold D, Schraven B, Reinhold A.
Immune Cell-Type Specific Ablation of Adapter Protein ADAP Differentially Modulates EAE.
Front Immunol. 2019 Oct 1;10:2343. doi: 10.3389/fimmu.2019.02343. eCollection 2019.

Rudolph JM, Guttek K, Weitz G, Meinke CA, Kliche S, Reinhold D, Schraven B, Reinhold A.
Characterization of mice with a platelet-specific deletion of the adapter molecule ADAP.
Mol Cell Biol. 2019 Mar 4. pii: MCB.00365-18. doi: 10.1128/MCB.00365-18 . [Epub ahead of print]

2018

Demiray YE, Rehberg K, Kliche S, Stork O.
Ndr2 Kinase Controls Neurite Outgrowth and Dendritic Branching Through α1 Integrin Expression.
Front Mol Neurosci. 2018 Mar 6;11:66. doi: 10.3389/fnmol.2018.00066 . eCollection 2018.

Edelmann B, Gupta N, Schnöder TM, Oelschlegel AM, Shahzad K, Goldschmidt J, Philipsen L, Weinert S, Ghosh A, Saalfeld FC, Nimmagadda SC, Müller P, Braun-Dullaeus RC, Mohr J, Wolleschak D, Kliche S, Amthauer H, Heidel FH, Schraven B, Isermann B, Müller A, Fischer T.
JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation.
J Clin Invest. 2018 Jul 19. pii: 90312. doi: 10.1172/JCI90312

Waldt N, Seifert A,  Demiray YE, Devroe E, Turk BE, Reichardt P, Mix C,  Reinhold A, Freund C, Mueller AJ, Schraven B*, Stork O*, Kliche S*.
Filamin A phosphorylation at serine 2152 by the serine/threonine kinase Ndr2 controls TCR-induced LFA-1 activation in T cells. 
Front Immunol. 2018 Dec 4;9:2852. doi: 10.3389/fimmu.2018.02852. eCollection 2018. *corresponding authors.

2017

Boras M, Volmering S, Bokemeyer A, Rossaint J, Block H, Bardel B, Van Marck V, Heitplatz B, Kliche S, Reinhold A, Lowell C, Zarbock A.
Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions.
J Exp Med. 2017 Feb 9. pii: jem.20160647. doi: 10.1084/jem.20160647. [Epub ahead of print]

Gupta N, Edelmann B, Schnoeder TM, Saalfeld FC, Wolleschak D, Kliche S, Schraven B, Heidel FH, Fischer T.
JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1.
Leukemia. 2017 Feb 10. doi: 10.1038/leu.2017.26. [Epub ahead of print]

Niemz J, Kliche S, Pils MC, Morrison E, Manns A, Freund C, Crittenden JR, Graybiel AM, Galla M, Jänsch L, Huehn J.
The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells.
Eur J Microbiol Immunol (Bp). 2017 May 22;7(2):112-126. doi: 10.1556/1886.2017.00007. eCollection 2017 Jun.

Parzmair GP, Gereke M, Haberkorn O, Annemann M, Podlasly L, Kliche S, Reinhold A, Schraven B, Bruder D.
ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens.
J Leukoc Biol. 2017 Feb;101(2):407-419. doi: 10.1189/jlb.1A0216-090RR.

Schneble N, Müller J, Kliche S, Bauer R, Wetzker R, Böhmer FD, Wang ZQ, Müller JP.
The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase.
Glia. 2017 Feb;65(2):416-428. doi: 10.1002/glia.23100.

van Ham M, Teich R, Philipsen L, Niemz J, Amsberg N, Wissing J, Nimtz M, Gröbe L, Kliche S, Thiel N, Klawonn F, Hubo M, Jonuleit H, Reichardt P, Müller AJ, Huehn J, Jänsch L.
TCR signalling network organization at the immunological synapses of murine regulatory T cells.
Eur J Immunol. 2017 Aug 17. doi: 10.1002/eji.201747041. [Epub ahead of print]

Witte A, Meineke B, Sticht J, Philipsen L, Kuropka B, Müller AJ, Freund C, Schraven B, Kliche S.
D120 and K152 within the PH domain of T cell adapter SKAP55 regulate plasma membrane targeting of SKAP55 and LFA-1 affinity modulation in human T lymphocytes.
Mol Cell Biol. 2017 Jan 4. pii: MCB.00509-16. doi: 10.1128/MCB.00509-16. [Epub ahead of print]

2016

Atypical IκB proteins in immune cell differentiation and function.
Immunol Lett. 2016 Mar;171:26-35. doi: 10.1016/j.imlet.2016.01.006. Epub  2016 Jan 22.

Danzer C, Koller A, Baier J, Arnold H, Giessler C, Opoka R, Schmidt S, Willers M, Mihai S, Parsch H, Wirtz S, Daniel C, Reinhold A, Engelmann S, Kliche S, Bogdan C, Hoebe K, Mattner J.
A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.
Eur J Immunol. 2016 Jun 28. doi: 10.1002/eji.201646331. [Epub ahead of print] PMID: 27349342

Kuropka B, Schraven B, Kliche S, Krause E, Freund C
Tyrosine-phosphorylation of the scaffold protein ADAP and its role in T cell signaling.
Expert Rev Proteomics. 2016 Jun;13(6):545-54. doi: 10.1080/14789450.2016.1187565. PMID: 27258783

Thiere M, Kliche S, Müller B, Teuber J, Nold I, Stork O.
Integrin Activation Through the Hematopoietic Adapter Molecule ADAP Regulates Dendritic Development of Hippocampal Neurons.
Front Mol Neurosci. 2016 Sep 30;9:91.PMID:27746719

2015

Engelmann S, Togni M, Kliche S, Reinhold D, Schraven B, Reinhold A.
The adhesion- and degranulation-promoting adaptor protein and its role in the modulation of experimental autoimmune encephalomyelitis.
Crit Rev Immunol. 2015;35(1):1-14.

Kuropka B, Witte A, Sticht J, Waldt N, Majkut P, Hackenberger CP, Schraven B, Krause E, Kliche S, Freund C.
Analysis of phosphorylation-dependent protein interactions of ADAP reveals novel interactions partners required for chemokine-directed T cell migration.
Mol Cell Proteomics. 2015 Aug 5. pii: mcp.M115.048249. [Epub ahead of print]

Morrison E, Kuropka B, Kliche S, Brügger B, Krause E, Freund C.
Quantitative analysis of the human T cell palmitome. 
Sci Rep. 2015 Jun 26;5:11598. doi: 10.1038/srep11598.

2014

Drynda A, Singh G, Buchhorn GH, Awiszus F, Ruetschi M, Feuerstein B, Kliche S, Lohmann CH.
Metallic wear debris may regulate CXCR4 expression in vitro and in vivo.
J Biomed Mater Res A. 2014 Sep 10. doi: 10.1002/jbm.a.35330. [Epub ahead of print]

Lettau M, Kliche S, Kabelitz D, Janssen O.
The adapter proteins ADAP and Nck cooperate in T cell adhesion.
Mol Immunol. 2014 Jul;60(1):72-9. doi: 10.1016/j.molimm.2014.03.017. Epub 2014 Apr 24.

Rehberg K, Kliche S, Madencioglu DA, Thiere M, Müller B, Meineke BM, Freund C, Budinger E, Stork O.
The serine/threonine kinase ndr2 controls integrin trafficking and integrin-dependent neurite growth.
J Neurosci. 2014 Apr 9;34(15):5342-54.

Wolleschak D, Mack TS, Perner F, Frey S, Schnoeder TM, Wagner MC, Höding C, Pils MC, Parkner A, Kliche S, Schraven B, Hebel K, Brunner-Weinzierl M, Ranjan S, Isermann B, Lipka DB, Fischer T, Heidel FH.
Clinically relevant doses of FLT3-kinase inhibitors Quizartinib and Midostaurin do not impair T-cell reactivity and function.
Haematologica. 2014 Mar 14. [Epub ahead of print]

2010 - 2013

Block H, Herter JM, Rossaint J, Stadtmann A, Kliche S, Lowell CA, Zarbock A.
Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.
J. Exp. Med. Vol. 2012; 209 No. 2 407-421

Burns JC, Corbo E, Degen J, Gohil M, Anterasian C, Schraven B, Koretzky GA, Kliche S, Jordan MS.
The SLP-76 Src Homology 2 Domain Is Required for T Cell Development and Activation.
J Immunol. 2011 Nov 1;187(9):4459-66. Epub 2011 Sep 26.

Engelmann S, Togni M, Thielitz A, Reichardt P, Kliche S, Reinhold D, Schraven B, Reinhold A.
T Cell-Independent Modulation of Experimental Autoimmune Encephalomyelitis in ADAP-Deficient Mice.
J Immunol. 2013 Oct 7. [Epub ahead of print]

Hansen W, Hutzler M, Abel S, Alter C, Stockmann C, Kliche S, Albert J, Sparwasser T, Sakaguchi S, Westendorf AM, Schadendorf D, Buer J, Helfrich I.
Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth.
J Exp Med. 2012 Oct 22;209(11):2001-16.

Kliche S, Worbs T, Wang X, Degen J, Patzak I, Meineke B, Togni M, Moser M, Reinhold A, Kiefer F, Freund C, Förster R, Schraven B.
CCR7-mediated LFA-1 functions in T cells are regulated by two independent ADAP/SKAP55-modules.
Blood. 2012;119(3):777-785

Lek HS, Morrison VL, Conneely M, Campbell PA, McGloin D, Kliche S, Watts C, Prescott A, Fagerholm SC. 
The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow.
J Biol Chem. 2013 May 24;288(21):14698-708. doi: 10.1074/jbc.M112.430918. Epub 2013 Apr 12.

Nishanth G, Sakowicz-Burkiewicz M, Händel U, Kliche S, Wang X, Naumann M, Deckert M, Schlüter D.
Protective Toxoplasma gondii-specific T-cell responses require T-cell-specific expression of protein kinase C-theta.
Infect Immun. 2010 Aug;78(8):3454-64.

Rubio I, Grund S, Song SP, Biskup C, Bandemer S, Fricke M, Förster M, Graziani A, Wittig U, Kliche S.
TCR-induced activation of Ras proceeds at the plasma membrane and requires palmitoylation of N-Ras.
J Immunol. 2010 Sep 15;185(6):3536-43. 20498263

Sylvester M, Kliche S, Lange S, Geithner S, Klemm C, Schlosser A, Grossmann A, Stelzl U, Schraven B, Krause E, Freund C.
Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells.
PLoS One. 2010 Jul 22;5(7):e11708.

Witte A, Degen J, Baumgart K, Waldt N, Kuropka B, Freund C, Schraven B, Kliche S.
Emerging Roles of ADAP, SKAP55, and SKAP-HOM for Integrin and NF-κB Signaling in T cells
Clinical & Cellular Immunology 2012, S12