2024

Franz T, Stegemann-Koniszewski S, Schreiber J, Müller A, Bruder D, Dudeck A, Boehme JD, Kahlfuss S.
Metabolic and ionic control of T cells in asthma endotypes.
Am J Physiol Cell Physiol. 2024 Oct 7. doi: 10.1152/ajpcell.00474.2024. Online ahead of print.

Haage TR, Charakopoulos E, Bhuria V, Baldauf CK, Korthals M, Handschuh J, Müller P, Li J, Harit K, Nishanth G, Frey S, Böttcher M, Fischer KD, Dudeck J, Dudeck A, Lipka DB, Schraven B, Green AR, Müller AJ, Mougiakakos D, Fischer T.
Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia.
J Hematol Oncol. 2024 Jun 9;17(1):43.

Kotrba J, Dudeck A.
Comment: Mast cells: The Janus of type 2 inflammation.
Immunity. 2024 Jun 11;57(6):1182-1184. doi: 10.1016/j.immuni.2024.05.011.

Kotrba J, Müller I, Pausder A, Hoffmann A, Camp B, Boehme JD, Müller A, Schreiber J, Bruder D, Kahlfuss S, Dudeck A, Stegemann-Koniszewski S.
Innate players in Th2 and non-Th2 asthma - emerging roles for the epithelial cell, mast cell and monocyte/macrophage network.
Am J Physiol Cell Physiol. 2024 Oct 14. doi: 10.1152/ajpcell.00488.2024. Online ahead of print.

Reichardt C, Brandt S, Bernhardt A, Krause A, Lindquist JA, Weinert S, Geffers R, Franz T, Kahlfuss S, Dudeck A, Mathew A, Rana R, Isermann B, Mertens PR.
DNA-binding protein-A promotes kidney ischemia/reperfusion injury and participates in mitochondrial function.
Kidney Int. 2024 May 29:S0085-2538(24)00379-X. Epub ahead of print.

2023

Fischer V, Bülow JM, Krüger BT, Ragipoglu D, Vikman A, Haffner-Luntzer M, Katsoulis-Dimitriou K, Dudeck A, Ignatius A.
Role of Mast-Cell-Derived RANKL in Ovariectomy-Induced Bone Loss in Mice.
Int J Mol Sci. 2023 May 23;24(11):9135.

2022

Fischer V, Ragipoglu D, Diedrich J, Steppe L, Dudeck A, Schütze K, Kalbitz M, Gebhard F, Haffner-Luntzer M, Ignatius A.
Mast Cells Trigger Disturbed Bone Healing in Osteoporotic Mice.
J Bone Miner Res. 2022 Jan;37(1):137-151.

Krone A, Fu Y, Schreiber S, Kotrba J, Borde L, Nötzold A, Thurm C, Negele J, Franz T, Stegemann-Koniszewski S, Schreiber J, Garbers C, Shukla A, Geffers R, Schraven B, Reinhold D, Dudeck A, Reinhold A, Müller AJ, Kahlfuss S.
Ionic mitigation of CD4+ T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc.
Sci Rep. 2022 Feb 4;12(1):1943. doi: 10.1038/s41598-022-04827-6.

Ragipoglu D, Bülow J, Hauff K, Voss M, Haffner-Luntzer M, Dudeck A, Ignatius A, Fischer V.
Mast Cells Drive Systemic Inflammation and Compromised Bone Repair After Trauma.
Front Immunol. 2022 Apr 26;13:883707. doi: 10.3389/fimmu.2022.883707.

2021

Dudeck J, Kotrba J, Immler R, Hoffmann A, Voss M, Alexaki VI, Morton L, Jahn SR, Katsoulis-Dimitriou K, Winzer S, Kollias G, Fischer T, Nedospasov SA, Dunay IR, Chavakis T, Müller AJ, Schraven B, Sperandio M, Dudeck A.
Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation.
Immunity. 2021 Jan 15:S1074-7613(20)30545-8. doi: 10.1016/j.immuni.2020.12.017.

Formaglio P, Alabdullah M, Siokis A, Handschuh J, Sauerland I, Fu Y, Krone A, Gintschel P, Stettin J, Heyde S, Mohr J, Philipsen L, Schröder A, Robert PA, Zhao G, Khailaie S, Dudeck A, Bertrand J, Späth GF, Kahlfuß S, Bousso P, Schraven B, Huehn J, Binder S, Meyer-Hermann M, Müller AJ.
Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells.
Immunity. 2021 Oct 15:S1074-7613(21)00406-4. doi: 10.1016/j.immuni.2021.09.021. Online ahead of print.

Jordan PM, Andreas N, Groth M, Wegner P, Weber F, Jäger U, Küchler C, Werz O, Serfling E, Kamradt T, Dudeck A, Drube S.
ATP/IL-33-triggered hyperactivation of mast cells results in an amplified production of pro-inflammatory cytokines and eicosanoids.
Immunology. 2021 Nov;164(3):541-554. doi: 10.1111/imm.13386. Epub 2021 Jun 30.

Prado Acosta M, Goyette-Desjardins G, Scheffel J, Dudeck A, Ruland J, Lepenies B.
S-Layer From Lactobacillus brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis.
Front Immunol. 2021 Mar 1;12:602067. doi: 10.3389/fimmu.2021.602067.

Schreiber S, Hammers CM, Kaasch AJ, Schraven B, Dudeck A, Kahlfuss S.
Metabolic Interdependency of Th2 Cell-Mediated Type 2 Immunity and the Tumor Microenvironment.
Frontiers in Immunology. 2021 May 31;12:632581. doi: 10.3389/fimmu.2021.632581. eCollection 2021.

Voss M, Kotrba J, Gaffal E, Katsoulis-Dimitriou K, Dudeck A.
Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?
Int J Mol Sci. 2021 Apr 27;22(9):4589. doi: 10.3390/ijms22094589.

2020

Böning MAL, Trittel S, Riese P, van Ham M, Heyner M, Voss M, Parzmair GP, Klawonn F, Jeron A, Guzman CA, Jänsch L, Schraven B, Reinhold A, Bruder D.
ADAP Promotes Degranulation and Migration of NK Cells Primed During in vivo Listeria monocytogenes Infection in Mice.
Front. Immunol., 22 January 2020. https://doi.org/10.3389/fimmu.2019.03144

Hoppe A, Katsoulis-Dimitriou K, Edler H, Dudeck J, Drube S, Dudeck A.
Mast cells initiate the vascular response to contact allergens by sensing cell stress.
J Allergy Clin Immunol. 2020 Feb 1. pii: S0091-6749(20)30125-1. doi: 10.1016/j.jaci.2020.01.036. [Epub ahead of print]

Katsoulis-Dimitriou K, Kotrba J, Voss M, Dudeck J, Dudeck A.
Mast Cell Functions Linking Innate Sensing to Adaptive Immunity.
Cells. 2020 Nov 25;9(12):E2538. doi: 10.3390/cells9122538.

Ragipoglu D, Dudeck A, Haffner-Luntzer M, Voss M, Kroner J, Ignatius A, Fischer V.
The Role of Mast Cells in Bone Metabolism and Bone Disorders.
Front Immunol. 2020 Feb 7;11:163. doi: 10.3389/fimmu.2020.00163. eCollection 2020.

Weitzmann A, Naumann R, Dudeck A, Zerjatke T, Gerbaulet A, Roers A.
Mast Cells Occupy Stable Clonal Territories in Adult Steady-State Skin.
J Invest Dermatol. 2020 Dec;140(12):2433-2441.e5. doi: 10.1016/j.jid.2020.03.963. Epub 2020 Apr 18.

2019

Dudeck J, Froebel J, Kotrba J, Lehmann CHK, Dudziak D, Speier S, Nedospasov SA, Schraven B, Dudeck A.
Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency.
J Allergy Clin Immunol. 2019 May;143(5):1849-1864.e4.

2018

Dudeck A, Köberle M, Goldmann O, Meyer N, Dudeck J, Lemmens S, Rohde M, Roldán NG, Dietze-Schwonberg K, Orinska Z, Medina E, Hendrix S, Metz M, Zenclussen AC, von Stebut E, Biedermann T.
Mast cells as protectors of health.
J Allergy Clin Immunol. 2018 Nov 20. pii: S0091-6749(18)31605-1. doi: 10.1016/j.jaci.2018.10.054. (in press)

Heyde S, Philipsen L, Formaglio P, Fu Y, Baars I, Höbbel G, Kleinholz C, Seiß EA, Stettin J, Gintschel P, Dudeck A, Bousso P, Schraven B, Müller AJ.
CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission.
PLoS Pathog. 2018 Oct 22;14(10):e1007374. doi: 10.1371/journal.ppat.1007374 . [Epub ahead of print]

Schubert N, Lisenko K, Auerbach C, Weitzmann A, Ghouse SM, Muhandes L, Haase C, Häring T, Schulze L, Voehringer D, Gunzer F, Müller W, Feyerabend TB, Rodewald HR, Dudeck A, Roers A.
Unimpaired Responses to Vaccination With Protein Antigen Plus Adjuvant in Mice With Kit-Independent Mast Cell Deficiency.
Front Immunol. 2018 Aug 28;9:1870. doi: 10.3389/fimmu.2018.01870 . eCollection 2018

2017

Biswas A, French T, Düsedau HP, Mueller N, Riek-Burchardt M, Dudeck A, Bank U, Schüler T, Dunay IR.
Behavior of Neutrophil Granulocytes during Toxoplasma gondii Infection in the Central Nervous System.
Front Cell Infect Microbiol. 2017 Jun 21;7:259. doi: 10.3389/fcimb.2017.00259. eCollection 2017.

Dudeck J, Medyukhina A, Fröbel J, Svensson CM, Kotrba J, Gerlach M, Gradtke AC, Schröder B, Speier S, Figge MT, Dudeck A.
Mast cells acquire MHCII from dendritic cells during skin inflammation.
J Exp Med. 2017 Dec 4;214(12):3791-3811. doi: 10.1084/jem.20160783. Epub 2017 Oct 30.

Drube S, Grimlowski R, Deppermann C, Fröbel J, Kraft F, Andreas N, Stegner D, Dudeck J, Weber F, Rödiger M, Göpfert C, Drube J, Reich D, Nieswandt B, Dudeck A, Kamradt T.
The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis.
J Immunol. 2017 Oct 15;199(8):2948-2957. doi: 10.4049/jimmunol.1700556. Epub 2017 Sep 8.

Kroner J, Kovtun A, Kemmler J, Messmann JJ, Strauss G, Seitz S, Schinke T, Amling M, Kotrba J, Froebel J, Dudeck J, Dudeck A*, Ignatius A.*
Mast Cells Are Critical Regulators of Bone Fracture-Induced Inflammation and Osteoclast Formation and Activity.
J Bone Miner Res. 2017 Dec;32(12):2431-2444. doi: 10.1002/jbmr.3234. Epub 2017 Sep 11. * equally contributing authors

Leist M, Sünder CA, Drube S, Zimmermann C, Geldmacher A, Metz M, Dudeck A*, Maurer M*.
Membrane-bound stem cell factor ist he major but not only driver of fibroblast-induced murine skin mast cell differentiation.
Exp Dermatol. 2017 Mar;26(3):255-262, * equally contributing authors

Reitz M, Brunn ML, Rodewald HR, Feyerabend TB, Roers A, Dudeck A, Voehringer D, Jönsson F, Kühl AA, Breloer M.
Mucosal mast cells are indispensable for the timely termination of Strongyloides ratti infection.
Mucosal Immunol. 2017 Mar;10(2):481-492.

selected former publications:

Drube S, Kraft F, Dudeck J, Müller AL, Weber F, Göpfert C, Meininger I, Beyer M, Irmler I, Häfner N, Schütz D, Stumm R, Yakovleva T, Gaestel M, Dudeck A, Kamradt T.
MK2/3 Are Pivotal for IL-33-Induced and Mast Cell-Dependent Leukocyte Recruitment and the Resulting Skin Inflammation.
J Immunol. 2016 Nov 1;197(9):3662-3668.

Dudeck J, Ghouse SM, Lehmann CH, Hoppe A, Schubert N, Nedospasov SA, Dudziak D, Dudeck A.
Mast-Cell-Derived TNF Amplifies CD8(+) Dendritic Cell Functionality and CD8(+) T Cell Priming.
Cell Rep. 2015 Oct 13;13(2):399-411. doi: 10.1016/j.celrep.2015.08.078.

Drube S, Weber F, Göpfert C, Loschinski R, Rothe M, Boelke F, Diamanti MA, Löhn T, Ruth J, Schütz D, Häfner N, Greten FR, Stumm R, Hartmann K, Krämer OH, Dudeck A, Kamradt T.
TAK1 and IKK2, novel mediators of SCFinduced signaling and potential targets for c-Kit-driven diseases.
Oncotarget. 2015 Oct 6;6(30):28833-50.

Peschke K, Dudeck A, Rabenhorst A, Hartmann K, Roers A.
Cre/loxP-based mouse models of mast cell deficiency and mast cell-specific gene inactivation.
Methods Mol Biol. 2015;1220:403-21.

Schubert N, Dudeck J, Liu P, Karutz A, Speier S, Maurer M, Tuckermann J, Dudeck A.
Mast cell promotion of T cell-driven antigen-induced arthritis despite being dispensable for antibody-induced arthritis in which T cells are bypassed.
Arthritis Rheumatol. 2015 Apr;67(4):903-13. doi: 10.1002/art.38996.

Weber FC, Németh T, Csepregi JZ, Dudeck A, Roers A, Ozsvári B, Oswald E, Puskás LG, Jakob T, Mócsai A, Martin SF.
Neutrophils are required for both the sensitization and elicitation phases of contact hypersensitivity.  
J. Exp. Med. 2015 Jan 12, 212:15-22.

Peschke K, Petzold A, Heger K, Schubert N, Scholten J, Voehringer D, Hartmann K, Dudeck A, Schmidt-Supprian M, Roers A.
IkB kinase 2 is essential for the IgE-induced mast cell late phase  cytokine response but is not required for mast cell degranulation.
2014 sep 11, Cell Rep. 8:1300-7.

De Filippo K,* Dudeck A*, Hasenberg M, Nye E, van Rooijen N, Hartmann K, Gunzer M, Roers A, and Hogg N.
Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation.
Blood. 2013 Jun 13, 121:4930-4937, *shared first authors

Dudeck A, Dudeck J, Scholten J, Petzold A, Surianarayanan S, Köhler A, Peschke K, Vöhringer D, Waskow C, Krieg T, Müller W, Waisman A, Hartmann K, Gunzer M, Roers A.
Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens.
Immunity. 2011 Jun 24;34(6):973-84. doi: 10.1016/j.immuni.2011.03.028.

Dudeck A, Suender CA, Kostka SL, von Stebut E, Maurer M.
Mast cells promote Th1 and Th17 responses by modulating dendritic cell maturation and function.
Eur J Immunol. 2011 Jul;41(7):1883-93. doi: 10.1002/eji.201040994.

Drube S, Heink S, Walter S, Löhn T, Grusser M, Gerbaulet A, Berod L, Schons J, Dudeck A, Freitag J, Grotha S, Reich D, Rudeschko O, Norgauer J, Hartmann K, Roers A, Kamradt T.
The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells.
Blood. 2010 May 13;115(19):3899-906.

Dudeck A, Leist M, Rubant S, Zimmermann A, Dudeck J, Boehncke WH, Maurer M.
Immature mast cells exhibit rolling and adhesion to endothelial cells and subsequent diapedesis triggered by E- and P-selectin, VCAM-1 and PECAM-1.
Exp Dermatol. 2010 May;19(5):424-34. doi: 10.1111/j.1600-0625.2010.01073.x.