INSTITUT FÜR MOLEKULARE UND KLINISCHE IMMUNOLOGIE

Publikationen

2024

Goihl A, Reinhold D, Reinhold A, Schraven B, Körtvelyessy P.
Leucine-Rich Glioma-Inactivated 1 (LGI1) Protein Stimulates Proliferation and IL-10 Production in Peripheral Blood Mononuclear Cells of Patients with LGI1 Antibody-Mediated Autoimmune Encephalitis In Vitro.
Int J Mol Sci. 2024 Feb 23;25(5):2581.

2023

Guttek K, Reinhold A, Grüngreiff K, Schraven B, Reinhold D.
Zinc aspartate induces proliferation of resting and antigen-stimulated human PBMC under high-density cell culture condition.
J Trace Elem Med Biol. 2023 Mar 11;77:127152.

Reinhold D, Reinhold A, Schraven B, Feist E.
[General knowledge of frequently applied test procedures in rheumatological and immunological diagnostics and research].
Z Rheumatol. 2023 Mar 3:1–6. German.

2022

Hammerschmidt SI, Thurm C, Bošnjak B, Bernhardt G, Reinhold A, Willenzon S, Ritter C, Reinhold D, Schraven B, Förster R.
Robust induction of neutralizing antibodies against the SARS-CoV-2 Delta variant after homologous Spikevax or heterologous Vaxzevria-Spikevax vaccination.
Eur J Immunol. 2022 Feb;52(2):356-359. doi: 10.1002/eji.202149645. Epub 2022 Jan 7.

Krone A, Fu Y, Schreiber S, Kotrba J, Borde L, Nötzold A, Thurm C, Negele J, Franz T, Stegemann-Koniszewski S, Schreiber J, Garbers C, Shukla A, Geffers R, Schraven B, Reinhold D, Dudeck A, Reinhold A, Müller AJ, Kahlfuss S.
Ionic mitigation of CD4+ T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc.
Sci Rep. 2022 Feb 4;12(1):1943. doi: 10.1038/s41598-022-04827-6.

Meltendorf S, Vogel K, Thurm C, Prätsch F, Reinhold A, Färber J, Heuft HG, Kaasch AJ, Hachenberg T, Weinzierl S, Schraven B, Reinhold D, Brunner-Weinzierl MC, Lingel H.
IL-13 determines specific IgE responses and SARS-CoV-2 immunity after mild COVID-19 and novel mRNA vaccination.
Eur J Immunol. 2022 Oct 22. doi: 10.1002/eji.202249951.

Spindler M, Bergmeier W, Stradal TEB, Zhang J, Siminovitch K, Nicolai L, Reinhold A, Bender M.
Novel insights into mouse models of ectopic proplatelet release.
Blood Adv. 2022 Oct 17:bloodadvances.2022007824.

Thurm C, Reinhold A, Borucki K, Kahlfuss S, Feist E, Schreiber J, Reinhold D, Schraven B.
Homologous and Heterologous Anti-COVID-19 Vaccination Does Not Induce New-Onset Formation of Autoantibodies Typically Accompanying Lupus Erythematodes, Rheumatoid Arthritis, Celiac Disease and Antiphospholipid Syndrome.
Vaccines (Basel). 2022 Feb 18;10(2):333.

2021

Böning MAL, Parzmair GP, Jeron A, Düsedau HP, Kershaw O, Xu B, Relja B, Schlüter D, Dunay IR, Reinhold A, Schraven B, Bruder D.
Enhanced Susceptibility of ADAP-Deficient Mice to Listeria monocytogenes Infection Is Associated With an Altered Phagocyte Phenotype and Function.
Front Immunol. 2021 Sep 30;12:724855. doi: 10.3389/fimmu.2021.724855. eCollection 2021. PMID: 346592

Dadwal N, Mix C, Reinhold A, Witte A, Freund C, Schraven B, Kliche S.
The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events.
Front Immunol. 2021 Jul 6;12:703534. doi: 10.3389/fimmu.2021.703534. eCollection 2021.

Reinhold D, Guttek K, Reddig A, Voss L, Schubert C, Kahlfuss S, Grüngreiff K, Schraven B, Reinhold A.
Zinc Aspartate Induces IL-16 Secretion and Apoptosis in Human T Cells.
Biomedicines. 2021 Mar 1;9(3):246. doi: 10.3390/biomedicines9030246.

Voss L, Guttek K, Reddig A, Reinhold A, Voss M, Simeoni L, Schraven B, Reinhold D.
Pitavastatin Is a Highly Potent Inhibitor of T-Cell Proliferation.
Pharmaceuticals (Basel). 2021 Jul 27;14(8):727. doi: 10.3390/ph14080727

Voss L, Guttek K, Reddig A, Reinhold A, Voss M, Schraven B, Reinhold D.
Screening of FDA-Approved Drug Library Identifies Adefovir Dipivoxil as Highly Potent Inhibitor of T Cell Proliferation.
Front Immunol. 2021 Jan 8;11:616570.

Voss L, Guttek K, Reddig A, Reinhold A, Voss M, Schraven B, Reinhold D.
Screening of FDA-Approved Drug Library Identifies Adefovir Dipivoxil as Highly Potent Inhibitor of T Cell Proliferation.
Front Immunol. 2021 Jan 8;11:616570. doi: 10.3389/fimmu.2020.616570. eCollection 2020.

2020

Böning MAL, Trittel S, Riese P, van Ham M, Heyner M, Voss M, Parzmair GP, Klawonn F, Jeron A, Guzman CA, Jänsch L, Schraven B, Reinhold A, Bruder D.
ADAP Promotes Degranulation and Migration of NK Cells Primed During in vivo Listeria monocytogenes Infection in Mice.
Front. Immunol., 22 January 2020.

Luecke E, Jeron A, Kroeger A, Bruder D, Stegemann-Koniszewski S, Jechorek D, Borucki K, Reinhold D, Reinhold A, Foellner S, Walles T, Hachenberg T, Schreiber J.
Eosinophilic pulmonary vasculitis as a manifestation of the hyperinflammatory phase of COVID-19.
J Allergy Clin Immunol. 2020 Oct 26:S0091-6749(20)31392-0. doi: 10.1016/j.jaci.2020.09.026. Online ahead of print.

2019

Busse M, Campe KJ, Nowak D, Schumacher A, Plenagl S, Langwisch S, Tiegs G, Reinhold A, Zenclussen AC.
IL-10 producing B cells rescue mouse fetuses from inflammation-driven fetal death and are able to modulate T cell immune responses.
Sci Rep. 2019 Jun 27;9(1):9335. doi: 10.1038/s41598-019-45860-2

Rudolph JM, Guttek K, Weitz G, Meinke CA, Kliche S, Reinhold D, Schraven B, Reinhold A.
Characterization of mice with a platelet-specific deletion of the adapter molecule ADAP.
Mol Cell Biol. 2019 Mar 4. pii: MCB.00365-18. doi: 10.1128/MCB.00365-18 . [Epub ahead of print]

Rudolph J, Meinke C, Voss M, Guttek K, Kliche S, Reinhold D, Schraven B, Reinhold A.
Immune Cell-Type Specific Ablation of Adapter Protein ADAP Differentially Modulates EAE.
Front Immunol. 2019 Oct 1;10:2343. doi: 10.3389/fimmu.2019.02343. eCollection 2019.

2018

Guttek K, Wagenbrett L, Reinhold A, Grüngreiff K, Reinhold D.
Zinc aspartate suppresses proliferation and Th1/Th2/Th17 cytokine production of pre-activated human T cells in vitro.
J Trace Elem Med Biol. 2018 Sep;49:86-90. doi: 10.1016/j.jtemb.2018.05.003. Epub 2018 May 4.

Straubel D, Thielitz A, Reinhold A, Grüngreiff K, Reinhold D.
Combined Treatment with Zinc Aspartate and Intravenous Immunoglobulins (IVIGs) Ameliorates Experimental Autoimmune Encephalomyelitis (EAE).
J Immunol Res. 2018 Sep 26;2018:5982169. doi: 10.1155/2018/5982169. eCollection 2018

Spindler M, van Eeuwijk JMM, Schurr Y, Nurden P, Nieswandt B, Stegner D, Reinhold A, Bender M.
ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia.
Blood. 2018 Aug 9;132(6):635-646. doi: 10.1182/blood-2018-01-829259. Epub 2018 Jun 27.

Waldt N, Seifert A,  Demiray YE, Devroe E, Turk BE, Reichardt P, Mix C,  Reinhold A, Freund C, Mueller AJ, Schraven B*, Stork O*, Kliche S*.
Filamin A phosphorylation at serine 2152 by the serine/threonine kinase Ndr2 controls TCR-induced LFA-1 activation in T cells. 
Front Immunol. 2018 Dec 4;9:2852. doi: 10.3389/fimmu.2018.02852. eCollection 2018.

2017

Boras M, Volmering S, Bokemeyer A, Rossaint J, Block H, Bardel B, Van Marck V, Heitplatz B, Kliche S, Reinhold A, Lowell C, Zarbock A.
Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions.
J Exp Med. 2017 Feb 9. pii: jem.20160647. doi: 10.1084/jem.20160647. [Epub ahead of print]

Jalsrai A, Reinhold A, Becker A.
Ethanol Iris tenuifolia extract reduces brain damage in a mouse model of cerebral ischaemia.
Phytother Res. 2017 Nov 23. doi: 10.1002/ptr.5981 . [Epub ahead of print]

Parzmair GP, Gereke M, Haberkorn O, Annemann M, Podlasly L, Kliche S, Reinhold A, Schraven B, Bruder D.
ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens.
J Leukoc Biol. 2017 Feb;101(2):407-419. doi: 10.1189/jlb.1A0216-090RR.

2016

Danzer C, Koller A, Baier J, Arnold H, Giessler C, Opoka R, Schmidt S, Willers M, Mihai S, Parsch H, Wirtz S, Daniel C, Reinhold A, Engelmann S, Kliche S, Bogdan C, Hoebe K, Mattner J.
A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.
Eur J Immunol. 2016 Jun 28. doi: 10.1002/eji.201646331. [Epub ahead of print] PMID: 27349342

Quist SR, Papakonstantinou E, Ambach A, Quist J, Göppner D, Reinhold A, Vlanti V, Franke I, Gollnick HP.
Verrucous lichen planus following contact sensitivity to implanted gentamicin-polymethylmethacrylate bead chains.
J Eur Acad Dermatol Venereol. 2016 Mar 1. doi: 10.1111/jdv.13623. [Epub ahead of print]

Tapia-Pérez JH, Preininger R, Kirches E, Reinhold A, Butzmann J, Prilloff S, Mawrin C, Schneider T.
Simultaneous Administration of Statins and Pioglitazone Limits Tumor Growth in a Rat Model of Malignant Glioma.
Anticancer Res. 2016 Dec;36(12):6357-6365.

2015

Engelmann S, Togni M, Kliche S, Reinhold D, Schraven B, Reinhold A.
The adhesion- and degranulation-promoting adaptor protein and its role in the modulation of experimental autoimmune encephalomyelitis.
Crit Rev Immunol. 2015;35(1):1-14.

Hasenberg A, Hasenberg M, Männ L, Neumann F, Borkenstein L, Stecher M, Kraus A, Engel DR, Klingberg A, Seddigh P, Abdullah Z, Klebow S, Engelmann S, Reinhold A, Brandau S, Seeling M, Waisman A, Schraven B, Göthert JR, Nimmerjahn F, Gunzer M.
Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes.
Nat Methods. 2015 Mar 16. doi: 10.1038/nmeth.3322. [Epub ahead of print]

Reddycherla AV, Meinert I, Reinhold A, Reinhold D, Schraven B, Simeoni L.
miR-20a Inhibits TCR-Mediated Signaling and Cytokine Production in Human Naïve CD4+ T Cells.
PLoS One. 2015 Apr 17;10(4):e0125311. doi: 10.1371/journal.pone.0125311. eCollection 2015.

Udelnow A, Jechorek D, Wex C, Klose S, Pech M, Reinhold A, Meyer F.
Possible role of TGF β1 in inflammatory pseudotumor associated with multiple neuroendocrine tumors of the small intestine.
Pathol Res Pract. 2015 Jul 3. pii: S0344-0338(15)00122-3. doi: 10.1016/j.prp.2015.06.005. [Epub ahead of print] PubMed PMID: 26293797.
 

2014

Fiedler A, Grecksch G, Reinhold A, Schraven B, Becker A.
Hippocampus-dependent learning in SKAP-HOM deficient mice.
Behav Brain Res. 2014 May 9;270C:125-130. doi: 10.1016/j.bbr.2014.04.051. [Epub ahead of print]

Schubert C, Guttek K, Grüngreiff K, Thielitz A, Bühling F, Reinhold A, Brocke S, Reinhold D.
Oral zinc aspartate treats experimental autoimmune encephalomyelitis.
Biometals. 2014 Dec;27(6):1249-62. doi: 10.1007/s10534-014-9786-8. Epub 2014 Aug 22.

2013

Engelmann S, Togni M, Thielitz A, Reichardt P, Kliche S, Reinhold D, Schraven B, Reinhold A.
T Cell-Independent Modulation of Experimental Autoimmune Encephalomyelitis in ADAP-Deficient Mice.
J Immunol. 2013 Oct 7. [Epub ahead of print]

2012

Kliche S, Worbs T, Wang X, Degen J, Patzak I, Meineke B, Togni M, Moser M, Reinhold A, Kiefer F, Freund C, Förster R, Schraven B.
CCR7-mediated LFA-1 functions in T cells are regulated by two independent ADAP/SKAP55-modules.
Blood. 2012;119(3):777-785

Togni M, Engelmann S, Reinhold D, Schraven B, Reinhold A.
The adapter protein ADAP is required for selected dendritic cell functions.
Cell Commun Signal. 2012 Jun 6;10(1):14.

2011

Schilling T, Kozian A, Senturk M, Huth C, Reinhold A, Hedenstierna G, Hachenberg T.
Effects of Volatile and Intravenous Anesthesia on the Alveolar and Systemic Inflammatory Response in Thoracic Surgical Patients.
Anesthesiology. 2011 Jul;115(1):65-74.

Letzte Änderung: 18.03.2024 - Ansprechpartner:

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